2005
Role of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17
Nowak L, Sanchez-Vives M, McCormick D. Role of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17. Journal Of Neuroscience 2005, 25: 1866-1880. PMID: 15716423, PMCID: PMC6725929, DOI: 10.1523/jneurosci.3897-04.2005.Peer-Reviewed Original ResearchConceptsHigh-contrast stimulationMembrane potential hyperpolarizationPotential hyperpolarizationCat primary visual cortexRole of synapticIntrinsic membrane propertiesPrimary visual cortexCat area 17Significant reductionHigh-contrast stimuliGray screenArea 17Synaptic mechanismsLack of stimulationVisual cortexArtificial scotomaRF sizeReceptive field dynamicsSine-wave gratingsSingle neuronsStimulationStrong visual stimuliHigh-contrast sine-wave gratingsHyperpolarizationVisual stimuli
2003
Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
Wang X, Liu Y, Sanchez-Vives M, McCormick D. Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex. Journal Of Neurophysiology 2003, 89: 3279-3293. PMID: 12649312, DOI: 10.1152/jn.00242.2003.Peer-Reviewed Original ResearchConceptsPrimary visual cortical neuronsVisual cortical slicesCellular mechanismsVisual cortical neuronsIntrinsic membrane propertiesPrimary visual cortexPossible cellular mechanismsSensory inputSlow afterhyperpolarizationIntrinsic ionic currentsCortical slicesLayer 2/3Cortical neuronsNeocortical neuronsIntracellular injectionV1 neuronsNeuronal responsesVisual cortexEfficient neural codingModel neuronsReal-world sensory inputsNeuronsIonic currentsProlonged changesSingle neurons
2001
ON THE CELLULAR AND NETWORK BASES OF EPILEPTIC SEIZURES
McCormick D, Contreras D. ON THE CELLULAR AND NETWORK BASES OF EPILEPTIC SEIZURES. Annual Review Of Physiology 2001, 63: 815-846. PMID: 11181977, DOI: 10.1146/annurev.physiol.63.1.815.Peer-Reviewed Original ResearchConceptsCerebral cortexEpileptic seizuresSynchronized burstsRhythmic burst dischargesSpike-wave activityIntrinsic membrane propertiesForm of seizuresPeriod of hyperpolarizationLoss of balanceRecurrent excitatory connectionsEpileptic syndromesSeizure dischargesPyramidal neuronsTonic depolarizationEpileptiform activitySeizure generationBurst dischargesInhibitory neuronsInhibitory influenceInterictal spikesNormal brain rhythmsSynaptic plasticityAction potentialsSeizuresMammalian forebrain
1997
SLEEP AND AROUSAL: Thalamocortical Mechanisms
McCormick D, Bal T. SLEEP AND AROUSAL: Thalamocortical Mechanisms. Annual Review Of Neuroscience 1997, 20: 185-215. PMID: 9056712, DOI: 10.1146/annurev.neuro.20.1.185.Peer-Reviewed Original ResearchConceptsThalamic reticular neuronsReticular neuronsCerebral cortex resultsCortical pyramidal cellsIntrinsic membrane propertiesBasal forebrainEnhanced excitabilityBrain stemMovement sleepAbsence seizuresTonic activityPyramidal cellsThalamocortical activitySleep rhythmsAnatomical interconnectionsCortex resultsThalamocortical mechanismsDifferent neurotransmittersParoxysmal eventsSpindle wavesRhythmic activitySpecific alterationsSleepSensory processingSlow waves
1986
Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance
McCormick D, Prince D. Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance. Nature 1986, 319: 402-405. PMID: 2418361, DOI: 10.1038/319402a0.Peer-Reviewed Original ResearchConceptsNeuronal activityCholinergic inhibitory mechanismSingle spike activityRole of acetylcholineApplication of acetylcholineCentral nervous systemIntrinsic membrane propertiesAcetylcholine inducesM2 subclassCholinergic actionCholinergic inhibitionCholinergic inputMuscarinic receptorsBurst dischargesExcitatory modulatorThalamic neuronesNervous systemSpike activityFiring patternsPotassium conductanceReticular neuronesAcetylcholineNeuronesReticular systemInhibitory mechanism