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Harlan Krumholz, MD, SM

Harold H. Hines, Jr. Professor of Medicine (Cardiology) and Professor in the Institute for Social and Policy Studies, of Investigative Medicine and of Public Health (Health Policy); Founder, Center for Outcomes Research and Evaluation (CORE)

Contact Information

Harlan Krumholz, MD, SM

Patient Care Location

Office Location

Mailing Address

  • Cardiovascular Medicine

    195 Church Street

    New Haven, CT 06510

    United States



Harlan Krumholz is a cardiologist and scientist at Yale University and Yale New Haven Hospital. He is the Harold H. Hines, Jr. Professor of Medicine. He is a leading expert in the science to improve the quality and efficiency of care, eliminate disparities and promote equity, improve integrity and transparency in medical research, engage patients in their care, and avoid wasteful practices. Recent efforts are focused on harnessing the digital transformation in healthcare to accelerate knowledge generation and facilitate the delivery of care aligned with each patient’s needs and preferences.

Dr. Krumholz is director of the Yale New Haven Hospital Center for Outcomes Research and Evaluation (CORE), an organization dedicated to improving health and health care through research, tools, and practices that produce discovery, heighten accountability, and promote better public health and clinical care. He co-founded and co-leads the Yale University Open Data Access (YODA) Project, designed to increase access to clinical research data and promote their use to generate new knowledge. He also co-founded and co-leads medRxiv, a non-profit preprint server for the medical and health sciences. He was a founding faculty co-director of the Yale Center for Research Computing.

Dr. Krumholz has been honored by membership in the National Academy of Medicine, the Association of American Physicians, and the American Society for Clinical Investigation. He was named a Distinguished Scientist of the American Heart Association and received their Award of Meritorious Achievement and their Clinical Research Prize. He served as a member of the Advisory Committee to the Director of the National Institutes of Health. Dr. Krumholz received the Friendship Award from the People’s Republic of China in recognition of his collaborative efforts to develop a national cardiovascular research network and was named by the Chinese Society of Cardiology as a Top-10 Distinguished International Cardiologist for his contributions to the development of cardiovascular medicine in China. He founded the American Heart Association’s Quality of Care and Outcomes Research Council and co-founded their annual conference. He was the founding editor of Circulation: Cardiovascular Quality and Outcomes; founding editor of CardioExchange, a social media site of the publisher of the New England Journal of Medicine; and editor of Journal Watch Cardiology of the New England Journal of Medicine. He was a founding Governor of the Patient-Centered Outcomes Research Institute. He is the incoming Editor-in-Chief of JACC, a pre-eminent cardiovascular medical journal.

He co-founded HugoHealth, a patient-centric platform to engage people as partners in research and clinical care, facilitate the secure acquisition and movement of digital health data, and promote learning health communities. He co-founded Refactor Health, an enterprise healthcare AI-augmented health data management company.

Before joining the Yale faculty in 1992, Dr. Krumholz received a BS (Biology) from Yale, an MD from Harvard Medical School, and a Masters in Health Policy and Management (SM) from the Harvard University School of Public Health. At Yale, he directed the Robert Wood Johnson Foundation Clinical Scholars Program from 1996-2017 and serves as Director Emeritus of the Yale National Clinician Scholars Program. Dr. Krumholz has published over 1500 articles and three books with an h-index of more than 230.

Education & Training

  • Fellow
    Beth Israel Hospital/Harvard Medical School (1992)
  • SM
    Harvard, Health Policy and Management (SM) (1992)
  • Chief Resident
    Moffitt Hospital/University of California, San Francisco (1989)
  • Resident
    University of California, San Francisco (1988)
  • MD
    Harvard University (1985)
  • BS
    Yale College, Biology (1980)

Honors & Recognition

AwardAwarding OrganizationDate
Clinical Research PrizeAmerican Heart Association2019
Top-10 Distinguished International Cardiologists (for contributions to the development of cardiovascular medicine in China)Chinese Society of Cardiology2018
Advisory Committee to the DirectorNational Institutes of Health2015
China Friendship AwardPeople's Republic of China2014
Quality of Care and Outcomes Research Outstanding Achievement AwardAmerican Heart Association2013
Distinguished Achievement AwardAmerican Heart Association2011
Board of TrusteesAmerican College of Cardiology Foundation2010
Board of DirectorsAmerican Board of Internal Medicine2010
Distinguished Scientist AwardAmerican Heart Association2010
Elected memberConnecticut Academy of Science and Engineering2008
Elected memberInstitute of Medicine of the National Academies2007
Award of Meritorious AchievementAmerican Heart Association2007
Elected memberAssociation of American Physicians2004
Elected memberAmerican Society for Clinical Investigation2000

Professional Service

American College of CardiologySteering Committee of the Hospital to Home (H2H) Initiative2009 - Present
Institute of MedicineEvidentiary Recommendations for Qualification of Surrogate Endpoints for Chronic Disease Risk Committee2008 - Present
National Cardiovascular Data RegistryInternational Strategy Work Group2008 - Present
American College of Cardiology/American Heart AssociationMethodology for the Selection and Creation of Performance Measures for Quantifying the Quality of Cardiovascular Care Writing Committee2008 - Present
National Heart, Lung, and Blood InstituteExpert Panel on Integrated CVD Risk Reduction in Adults and the Guidelines Implementation Work Group2008 - Present
National Academy of Sciences, National Academy of Engineering, Institute of MedicineCommittee on Human Rights2008 - Present
American Heart AssociationStandards for Measures Used for Public Reporting of Efficiency and Value in Health Care Writing Group2007 - 2009
American College of Cardiology/American Heart AssociationWriting Group to Update the 2004 Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction, of the June 2007 Focused Update of the 2004 Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction2007 - 2009
American Heart AssociationImplementation and Integration of Pre-hospital Electrocardiogram Programs into Systems of Care for Acute Coronary Syndrome Writing Group2007 - 2008
Yale School of MedicineMD-MHS Advisory Committee2007 - Present
American College of CardiologyD2B Alliance Steering Committee2006 - 2008
American College of Cardiology/American Heart AssociationTask Force on Practice Guidelines2006 - 2008
American Heart AssociationScience Advisory and Coordinating Committee2006 - Present
Yale School of MedicineAdvisory Board2005 - Present
American Heart AssociationStandards for Statistical Models Used for Public Reporting of Outcomes Writing Group2004 - 2005
Yale School of MedicineClinical and Population-Based Research Committee2004 - Present
Yale School of NursingExternal Advisory Committee2003 - Present
Yale School of NursingCommittee Member2003 - Present
American College of Cardiology/American Heart AssociationWriting Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction2001 - 2005
American College of Cardiology/American Heart AssociationWriting Committee to Develop Performance Measures for STEMI/NSTEMI2000 - 2008
American College of Physicians-American Society of Internal MedicineFellow1999 - Present
American Heart AssociationFellow, Council on Clinical Cardiology1996 - Present
American College of CardiologyFellow1996 - Present

Departments & Organizations