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YCVRC Research Programs

Cardiovascular Development

Formation of heart and vasculature follow a complex series of steps that involve interplay of stimulatory and inhibitory signaling, guidance molecules and cross-talk among numerous cell types. A growing understanding of these events is already shedding light on many complex clinical problems and will likely result in development of new regenerative approaches to the treatment of a wide variety of cardiac illnesses. The following areas are being studied by Yale Cardiovascular Research Center investigators:

Vascular and lymphatic development

Large vessel development

Hemogenic endothelium

Neurovascular Biology

The vascular and the nervous system are the first two systems to develop, and they share a remarkable number of features including the overall network architecture and many signaling molecules and receptors. In addition, there is a remarkable cross-talk between the two systems with peripheral nerves guiding development of peripheral arteries and arterial blood supply supporting nerve growth. This interaction extends even further with the vasculature playing an important role in modulating nervous system plasticity during development and in adult tissues.

Neural guidance of the vasculature

  • Ensign Professor of Medicine (Cardiovascular Medicine) and Professor of Cellular And Molecular Physiology; Co-Director, Yale Cardiovascular Research Center (YCVRC)

Neurovascular CNS niche


Cellular responses to a variety of soluble and extracellular matrix signals are at the heart cardiovascular biology. A thorough understanding of this process can guide understanding of numerous cardiovascular pathologies from formation of arterial-venous malformations to development of cardiac hypertrophy to blood pressure regulation. The ability to manipulate these signaling events is critical to development of new classes of therapeutic agents that can promote process such as arteriogenesis or lymphangiogenesis, increase contractility of the failing heart or reverse myocardial hypertrophy.

Endothelial and smooth muscle signaling

Myocardial signaling


Technology advances in DNA sequencing and array analysis of gene expression have enabled comprehensive approaches to the analysis of many common and not so common cardiovascular problems. The genetics program seeks to understand genetic basis of a number of cardiovascular illnesses including early onset coronary artery disease, metabolic syndrome, sudden cardiac death and atrial fibrillation. Much of this work is carried out in close collaboration with CV geneticists at UCL.

Genetics, genomics & pharmacogenomics

Stem Cells

The goal of stem cell biology investigations at the Yale Cardiovascular Research Center is to develop a thorough understanding of processes involved in cell differentiation with the view towards developments of stem cell-based regenerative therapies for cardiac and neurological diseases. At the same time, investigators are exploring the utility of iPS-derived defined cell types from patients with complex illnesses for molecular diagnostics. These investigations are being carried out in close collaborations with Department of Neurology, Yale Stem Cell Center and UCL

Stem Cell

Faculty Research Matrix

Akar Atrial fibrillation Remodeling, Inflammation, Pericardial Fat, telemonitoring
Bender Vascular biology, immunology, inflammation Integrins, RNA stability, estrogen receptors
Burg Clinical research Anger
Chun Vascular biology, atherosclerosis Apelin, APJ, pulmonary artery
Curtis Health Services Research Measure development; Device effectiveness
Eichmann Developmental biology, vascular biology, neurovascular guidance Axon guidance receptors (Neuropilin,Robo, Netrin, Unc5b) Retina, embryo
Giordano Myocardial biology, metabolism, vascular biology HIF, VHL
Goldstein Transplant immunology, aging biology TLR, native immunity
Greif Developmental biology Pulmonary artery
Hirschi Developmental biology, hemogenic endothelium, neural regeneration hES, vascular niche, mouse, chardonnay
Hwa GPCR structure/function, signaling, cardiovascular pharmacogenetics GPCR, prostaglandins, atherothrombosis, pharmacogenetics
Jin Developmental biology, vascular biology BMP, hemogenic endothelium, zebrafish
Krumholz Health services research Health care policy
Lampert Electrophysiology, stress, ICDs Stress; ICDs
Lansky Interventional Clinical Research IVUS, OCT, angiography,
Mani Cardiovascular genetics, atherosclerosis LRP5
Martin Vascular biology, signaling Smooth muscle cell, mTOR, adiponectin
McNamara Outcomes research, CV Imaging Coronary Artery Disease, atrial fibrillation, Interventional comparisons
Nicoli Developmental biology, vascular development miRNA, zebrafish
Cardiovascular stem cell biology, cardiac development, cardiovascular tissue engineering
iPS, ES, Is11, Wnt
Sadeghi Molecular imaging, vascular biology Vascular remodeling, atherosclerosis, aneurysm, transplant vasculopathy, inflammation, MMPsa, av integrins, VEGF, ESDN
Schwartz Vascular biology, signaling Integrins, mechanotrasnsduction
Simons Vascular biology, developmental biology, signaling VEGF, FGF, synectin, syndecan-4
Sinusas Molecular imaging αvβ3, nanoparticles,
Soufer Mental Stress, Myocardial Ischemia Neuro-Cardiology,PET, MPI
Sugeng Clinical imaging 3D echocardiography
Tirziu Vascular biology, myocardial biology, signaling PlGF, EC-myocyte cross-talk
Young myocardial biology AMPK, stress response
Zhuang CV imaging & surgical/interventional procedure Micro-CT, molecular imaging (FXIII), animal models