2022
Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients
Dhaher R, Bronen RA, Spencer L, Colic L, Brown F, Mian A, Sandhu M, Pittman B, Spencer D, Blumberg HP, Altalib H. Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients. Epilepsia 2022, 63: 2561-2570. PMID: 35883245, DOI: 10.1111/epi.17377.Peer-Reviewed Original ResearchMeSH KeywordsDepressive Disorder, MajorElectroencephalographyEpilepsyEpilepsy, Temporal LobeHumansMagnetic Resonance ImagingSeptal NucleiConceptsTemporal lobe epilepsyDorsal bed nucleusTLE patientsEpilepsy patientsBed nucleusHC subjectsStria terminalisTemporal lobe epilepsy patientsMini International Neuropsychiatric InterviewMagnetic resonance imaging (MRI) scansTreatment-resistant depressionComprehensive Epilepsy CenterHealthy control subjectsStructural magnetic resonance imaging (MRI) scansResonance imaging scansNumber of patientsCase-control studyInternational Neuropsychiatric InterviewMajor depressive disorderCommon comorbid disordersHuman clinical studiesEpilepsy centersLobe epilepsyComorbid depressionControl subjects
2021
Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles.
Sandhu MRS, Mandel M, McGrath H, Lamsam L, Farooque P, Bronen RA, Spencer DD, Damisah EC. Management of patients with medically intractable epilepsy and anterior temporal lobe encephaloceles. Journal Of Neurosurgery 2021, 136: 709-716. PMID: 34507290, DOI: 10.3171/2021.3.jns21133.Peer-Reviewed Original ResearchMeSH KeywordsDrug Resistant EpilepsyElectroencephalographyEncephaloceleEpilepsy, Temporal LobeHumansMagnetic Resonance ImagingSeizuresTemporal LobeTreatment OutcomeConceptsTemporal lobe encephaloceleIdiopathic intracranial hypertensionRefractory epilepsyEEG findingsSigns of IIHIntractable temporal lobe epilepsyResective epilepsy surgeryManagement of patientsTemporal lobe epilepsyScalp EEG findingsSignificant neuropsychological deficitsRadiological findingsIntracranial hypertensionPreoperative evaluationEpileptogenic lesionsSurgical managementEpilepsy surgeryLobe epilepsySurgical outcomesIntractable epilepsySingle institutionSurgical dataEpileptogenic focusMedical recordsWorse outcomes
1998
MR of mesial temporal sclerosis: how much is enough?
Bronen R. MR of mesial temporal sclerosis: how much is enough? American Journal Of Neuroradiology 1998, 19: 15-8. PMID: 9432152, PMCID: PMC8337351.Commentaries, Editorials and Letters
1997
Topographic distribution of seizure onset and hippocampal atrophy: Relationship between MRI and depth EEG
King D, Bronen R, Spencer D, Spencer S. Topographic distribution of seizure onset and hippocampal atrophy: Relationship between MRI and depth EEG. Clinical Neurophysiology 1997, 103: 692-697. PMID: 9546496, DOI: 10.1016/s0013-4694(97)00090-4.Peer-Reviewed Original ResearchMeSH KeywordsAtrophyBrain MappingElectrodes, ImplantedElectroencephalographyEpilepsy, Temporal LobeFunctional LateralityHippocampusHumansMagnetic Resonance ImagingConceptsMedial temporal lobe epilepsyMagnetic resonance imagingSegmental atrophyHippocampal atrophyIctal onsetCell lossTopographic distributionDepth EEGHippocampal cell lossAnterior temporal lobectomyTemporal lobe epilepsyHippocampal depth electrodesMedial temporal structuresDistribution of onsetMost patientsTemporal lobectomyFocal onsetLobe epilepsyExcellent outcomesIctal recordingsDentate gyrusHippocampal segmentsSeizure onsetSubdural stripsDepth electrode contactsQualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery.
Bronen RA, Fulbright RK, King D, Kim JH, Spencer SS, Spencer DD, Lange RC. Qualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery. American Journal Of Roentgenology 1997, 169: 875-82. PMID: 9275915, DOI: 10.2214/ajr.169.3.9275915.Peer-Reviewed Original ResearchConceptsFebrile seizure historyTemporal lobe epilepsyRefractory temporal lobe epilepsyHippocampal sclerosisSeizure historySeizure outcomeLobe epilepsyHistologic findingsNonspecific gliosisHippocampal atrophyIntractable temporal lobe epilepsyMild hippocampal atrophySimilar clinical conditionsMR imaging diagnosisPositive predictive valueMR imagesSignal intensity changesSegmental findingsNormal findingsClinical parametersNeuronal densityRetrospective studyClinical conditionsSclerosisSurgeryPostoperative changes in the brain: MR imaging findings in patients without neoplasms.
Sato N, Bronen R, Sze G, Kawamura Y, Coughlin W, Putman C, Spencer D. Postoperative changes in the brain: MR imaging findings in patients without neoplasms. Radiology 1997, 204: 839-46. PMID: 9280269, DOI: 10.1148/radiology.204.3.9280269.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBrainChildDura MaterEpilepsy, Temporal LobeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedTemporal LobeTime FactorsConceptsPostoperative MR imagesPostoperative changesDural enhancementEnhancement patternThin linear enhancementContrast enhancement patternMagnetic resonance imagingMR imagesSurgical marginsTemporal lobectomyNeoplastic changesExtraaxial fluidIntracranial airContrast material-enhanced MR imagesDay 5Day 51Day 30Resonance imagingSurgeryBrainPatientsTime courseContrast enhancementLinear enhancementDays
1995
Regional distribution of MR findings in hippocampal sclerosis.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD, al-Rodhan NR. Regional distribution of MR findings in hippocampal sclerosis. American Journal Of Neuroradiology 1995, 16: 1193-200. PMID: 7677010, PMCID: PMC8337833.Peer-Reviewed Original ResearchConceptsHippocampal sclerosisHippocampal bodyHippocampal headMR findingsHippocampal tailMR abnormalitiesLimbic structuresAbnormal MR findingsConsecutive patientsIpsilateral hippocampusMost patientsSignal changesSeizure generatorPathologic analysisHyperintense signalRegional atrophyEntire hippocampusPatientsSclerosisHippocampusAmygdalaAtrophyMR changesMR scansWidespread involvement
1992
Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function
Lencz T, McCarthy G, Bronen R, Scott T, Inserni J, Sass K, Novelly R, Kim J, Spencer D. Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function. Annals Of Neurology 1992, 31: 629-637. PMID: 1514774, DOI: 10.1002/ana.410310610.Peer-Reviewed Original ResearchConceptsControl subjectsLeft temporal lobeTemporal lobeSeizure focusNeuronal densityHippocampal measurementsRight-handed control subjectsMagnetic resonance imagesHippocampal neuronal densityTemporal lobe originEpileptic temporal lobeTemporal lobe epilepsySignificant correlationQuantitative magnetic resonanceRefractory epilepsyLobe epilepsyPatient groupSelective Reminding TestHippocampal ratioLeft hippocampusHippocampal subfieldsPatientsWechsler Memory ScaleNeuropsychological functionHippocampus
1991
Imaging findings in hippocampal sclerosis: correlation with pathology.
Bronen R, Cheung G, Charles J, Kim J, Spencer D, Spencer S, Sze G, McCarthy G. Imaging findings in hippocampal sclerosis: correlation with pathology. American Journal Of Neuroradiology 1991, 12: 933-40. PMID: 1950925, PMCID: PMC8333515.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCell CountEpilepsy, Temporal LobeHippocampusHumansMagnetic Resonance ImagingMiddle AgedNeuronsSclerosisTemporal LobeConceptsTemporal lobe epilepsyCryptogenic temporal lobe epilepsyHippocampal sclerosisLobe epilepsyHippocampal atrophyNeuronal densityPathologic criteriaQualitative histologic findingsUnilateral hippocampal atrophyNeuronal cell lossImportant therapeutic consequencesPreoperative radiologic imagingAdjacent white matterLong TR scansGranular cell layerTemporal lobectomyPreoperative diagnosisIntractable epilepsyRadiologic imagingHistologic findingsSurgical specimensCornu ammonisTherapeutic consequencesMR findingsTemporal lobe