2022
The changing landscape in epilepsy imaging: Unmasking subtle and unique entities
Adin ME, Department of Radiology and Biomedical Imaging Y, Durand D, Zucconi W, Huttner A, Spencer D, Bronen R, Department of Radiology Abbott Northwestern Hospital M, Department of Pathology Y, Department of Neurosurgery Y. The changing landscape in epilepsy imaging: Unmasking subtle and unique entities. Diagnostic And Interventional Radiology 2022, 28: 503-515. PMID: 35997478, PMCID: PMC9682800, DOI: 10.5152/dir.2022.21339.Peer-Reviewed Original ResearchConceptsHippocampal sclerosisCortical developmentLocalization-related epilepsyTemporal lobe encephaloceleFocal cortical dysplasiaFocal cortical dysplasia IIbField of epilepsyEpileptogenic abnormalitiesAutoimmune encephalitisRasmussen's encephalitisCommon etiologyCortical dysplasiaEpilepsy surgeryEpileptogenic substrateTuberous sclerosisEpilepsy imagingHippocampal malformationsMTOR pathwayEncephalitisSclerosisMR imagingMalformationsUnique entitySurgeryEpilepsy
2000
Choroid plexus changes after temporal lobectomy.
Saluja S, Sato N, Kawamura Y, Coughlin W, Putman C, Spencer D, Sze G, Bronen R. Choroid plexus changes after temporal lobectomy. American Journal Of Neuroradiology 2000, 21: 1650-3. PMID: 11039344, PMCID: PMC8174865.Peer-Reviewed Original ResearchConceptsTemporal lobectomyChoroid plexusPostoperative changesResection siteNormal postoperative changesRecurrent brain tumorsContrast-enhanced T1-weighted imagesPresence of infectionContrast-enhanced MR imagingDegree of enhancementT1-weighted imagesChoroid plexus changesHippocampal sclerosisRecurrent tumorsIntractable epilepsyNodular patternPathologic changesPostoperative siteLobectomyBrain tumorsEnhancement patternSurgical manipulationPlexusMorphologic changesMR imaging
1997
Qualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery.
Bronen RA, Fulbright RK, King D, Kim JH, Spencer SS, Spencer DD, Lange RC. Qualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery. American Journal Of Roentgenology 1997, 169: 875-82. PMID: 9275915, DOI: 10.2214/ajr.169.3.9275915.Peer-Reviewed Original ResearchConceptsFebrile seizure historyTemporal lobe epilepsyRefractory temporal lobe epilepsyHippocampal sclerosisSeizure historySeizure outcomeLobe epilepsyHistologic findingsNonspecific gliosisHippocampal atrophyIntractable temporal lobe epilepsyMild hippocampal atrophySimilar clinical conditionsMR imaging diagnosisPositive predictive valueMR imagesSignal intensity changesSegmental findingsNormal findingsClinical parametersNeuronal densityRetrospective studyClinical conditionsSclerosisSurgeryA systematic approach for interpreting MR images of the seizure patient.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD. A systematic approach for interpreting MR images of the seizure patient. American Journal Of Roentgenology 1997, 169: 241-7. PMID: 9207533, DOI: 10.2214/ajr.169.1.9207533.Peer-Reviewed Original ResearchConceptsSubtle cortical abnormalitiesFalse-negative diagnosesHippocampal sclerosisAbnormal findingsEpileptogenic lesionsCortical thickeningSeizure patientsCortical abnormalitiesLateral ventriclePeriventricular regionEpilepsy patientsMR findingsHigh indexMorphologic abnormalitiesPeriventricular heterotopiaDual abnormalitiesGray matterDevelopmental anomaliesAbnormalitiesMR scansCortical processesMass effectHead rotationPatientsHippocampus
1996
Medial temporal lobe epilepsy without hippocampal atrophy
King D, Spencer S, Bouthillier A, Kim J, de Lanerolle N, Bronen R, McCarthy G, Luby M, Spencer D. Medial temporal lobe epilepsy without hippocampal atrophy. Epilepsy Research 1996, 9: 291-297. DOI: 10.1016/s0896-6974(96)00039-4.Peer-Reviewed Original ResearchMedial temporal lobe epilepsyHippocampal atrophyTemporal lobe epilepsyHippocampal sclerosisTemporal lobectomyLobe epilepsyMagnetic resonance imaging (MRI) volumetric studiesPresence of HADuration of epilepsyAnteromedial temporal lobectomyQuantitative cell countsPathologic evidenceSurgical outcomesClinical syndromeSeizure onsetPatientsCell countEpilepsyDepth EEGLonger durationAtrophyIncidenceVolumetric studiesInsufficient localizationOutcomes
1995
Regional distribution of MR findings in hippocampal sclerosis.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD, al-Rodhan NR. Regional distribution of MR findings in hippocampal sclerosis. American Journal Of Neuroradiology 1995, 16: 1193-200. PMID: 7677010, PMCID: PMC8337833.Peer-Reviewed Original ResearchConceptsHippocampal sclerosisHippocampal bodyHippocampal headMR findingsHippocampal tailMR abnormalitiesLimbic structuresAbnormal MR findingsConsecutive patientsIpsilateral hippocampusMost patientsSignal changesSeizure generatorPathologic analysisHyperintense signalRegional atrophyEntire hippocampusPatientsSclerosisHippocampusAmygdalaAtrophyMR changesMR scansWidespread involvement
1992
Epilepsy: the role of MR imaging.
Bronen R. Epilepsy: the role of MR imaging. American Journal Of Roentgenology 1992, 159: 1165-74. PMID: 1442376, DOI: 10.2214/ajr.159.6.1442376.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMR imagingTemporal lobe epilepsyLong TR imagesPositron emission tomographySingle photon emissionEpileptogenic abnormalitiesHippocampal sclerosisPreoperative evaluationSurgical treatmentLobe epilepsyHigh success rateCommon causeUncontrollable seizuresEmission tomographyTechnique of choiceEpilepsyFunctional imagingSuccess ratePatientsSeizuresTR imagesImagingTomographyMRSclerosis
1991
Imaging findings in hippocampal sclerosis: correlation with pathology.
Bronen R, Cheung G, Charles J, Kim J, Spencer D, Spencer S, Sze G, McCarthy G. Imaging findings in hippocampal sclerosis: correlation with pathology. American Journal Of Neuroradiology 1991, 12: 933-40. PMID: 1950925, PMCID: PMC8333515.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyCryptogenic temporal lobe epilepsyHippocampal sclerosisLobe epilepsyHippocampal atrophyNeuronal densityPathologic criteriaQualitative histologic findingsUnilateral hippocampal atrophyNeuronal cell lossImportant therapeutic consequencesPreoperative radiologic imagingAdjacent white matterLong TR scansGranular cell layerTemporal lobectomyPreoperative diagnosisIntractable epilepsyRadiologic imagingHistologic findingsSurgical specimensCornu ammonisTherapeutic consequencesMR findingsTemporal lobeMRI of the temporal lobe: Normal variations, with special reference toward epilepsy
Bronen R, Cheung G. MRI of the temporal lobe: Normal variations, with special reference toward epilepsy. Magnetic Resonance Imaging 1991, 9: 501-507. PMID: 1779721, DOI: 10.1016/0730-725x(91)90036-l.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingTemporal hornTemporal lobeCollateral sulcusCoronal magnetic resonance imagingTemporal horn dilatationMild asymmetryRight temporal lobeTemporal lobe structuresHippocampal sclerosisChoroidal fissureNormal variationMild enlargementFrequent findingHippocampal headNormal volunteersWhite matterAlzheimer's diseaseResonance imagingLobe structuresOccipitotemporal sulcusAdjacent vesselsHead rotationSclerosisSulcus