2022
Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchMeSH KeywordsAppetiteCerebrovascular CirculationGlucocorticoidsHumansHungerHydrocortisoneInsulinMagnetic Resonance ImagingConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networks
2018
Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging
Cline GW, Naganawa M, Chen L, Chidsey K, Carvajal-Gonzalez S, Pawlak S, Rossulek M, Zhang Y, Bini J, McCarthy TJ, Carson RE, Calle RA. Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging. Diabetologia 2018, 61: 2598-2607. PMID: 29721633, DOI: 10.1007/s00125-018-4624-0.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes Mellitus, Type 2FemaleHumansInsulin-Secreting CellsMagnetic Resonance ImagingMaleMiddle AgedPancreasPositron-Emission TomographyVesicular Monoamine Transport ProteinsConceptsVesicular monoamine transporter type 2Type 2 diabetesBeta-cell massHealthy obese volunteersStandardised uptake value ratioBeta-cell functionTest-retest variabilityPancreas headTracer uptakeSUVR-1Type 2 diabetes mellitusType 2 diabetic participantsBeta-cell capacityConclusions/interpretationTheC-peptide AUCImpaired glucose toleranceType 2 diabetes pathophysiologyCell functionDeficient insulin secretionAcute insulin responsePancreas of humansUptake value ratioC-peptide releasePancreatic polypeptide cellsTransporter type 2
2016
In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models
Pérez-Medina C, Binderup T, Lobatto ME, Tang J, Calcagno C, Giesen L, Wessel CH, Witjes J, Ishino S, Baxter S, Zhao Y, Ramachandran S, Eldib M, Sánchez-Gaytán BL, Robson PM, Bini J, Granada JF, Fish KM, Stroes ES, Duivenvoorden R, Tsimikas S, Lewis JS, Reiner T, Fuster V, Kjær A, Fisher EA, Fayad ZA, Mulder WJ. In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models. JACC Cardiovascular Imaging 2016, 9: 950-961. PMID: 27236528, PMCID: PMC5589956, DOI: 10.1016/j.jcmg.2016.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisAutoradiographyDisease Models, AnimalFemaleFlow CytometryLipoproteins, HDLMagnetic Resonance ImagingMaleMice, Inbred C57BLMice, KnockoutMolecular ImagingOptical ImagingPlaque, AtheroscleroticPositron Emission Tomography Computed TomographyPredictive Value of TestsRabbitsRadioisotopesRadiopharmaceuticalsReproducibility of ResultsTissue DistributionZirconiumConceptsHigh-density lipoproteinPositron emission tomographyHDL nanoparticlesPlaque macrophagesPET imagingAtherosclerotic plaque macrophagesRadioactivity uptake valuesIncident cardiovascular eventsCoronary heart diseaseDistinct pharmacokinetic profileStrong independent predictorHDL cholesterol concentrationsReverse cholesterol transportAdvanced atherosclerotic lesionsAccumulation of radioactivityMagnetic resonance imagingVivo PET imagingNoninvasive imaging toolNoninvasive PET imagingCardiovascular eventsIndependent predictorsAtherosclerosis modelHeart diseaseMurine modelAtherosclerotic lesions
2015
Attenuation Correction for Magnetic Resonance Coils in Combined PET/MR Imaging A Review
Eldib M, Bini J, Faul DD, Oesingmann N, Tsoumpas C, Fayad ZA. Attenuation Correction for Magnetic Resonance Coils in Combined PET/MR Imaging A Review. PET Clinics 2015, 11: 151-160. PMID: 26952728, PMCID: PMC4785842, DOI: 10.1016/j.cpet.2015.10.004.Peer-Reviewed Original ResearchMarkerless attenuation correction for carotid MRI surface receiver coils in combined PET/MR imaging
Eldib M, Bini J, Robson PM, Calcagno C, Faul DD, Tsoumpas C, Fayad ZA. Markerless attenuation correction for carotid MRI surface receiver coils in combined PET/MR imaging. Physics In Medicine And Biology 2015, 60: 4705-4717. PMID: 26020273, PMCID: PMC4495953, DOI: 10.1088/0031-9155/60/12/4705.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsCarotid Artery DiseasesFemaleFluorodeoxyglucose F18HumansImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMalePatient PositioningPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsSoftwareTissue DistributionTomography, X-Ray Computed
2014
Attenuation Correction for Flexible Magnetic Resonance Coils in Combined Magnetic Resonance/Positron Emission Tomography Imaging
Eldib M, Bini J, Calcagno C, Robson PM, Mani V, Fayad ZA. Attenuation Correction for Flexible Magnetic Resonance Coils in Combined Magnetic Resonance/Positron Emission Tomography Imaging. Investigative Radiology 2014, 49: 63-69. PMID: 24056110, PMCID: PMC4011564, DOI: 10.1097/rli.0b013e3182a530f8.Peer-Reviewed Original ResearchConceptsMagnetic resonance coilVolume splineResonance coilsMR coilPhantom experimentsSuch coilsUniform cylindrical water phantomMR/PET systemAttenuation propertiesCoilLocal overestimationAttenuation mapFlexible coilCylindrical water phantomPhantom findingsLocal underestimationRegistration methodAccurate measurementField of viewCT-based attenuation mapPhantom scansWater phantomAttenuation correctionSurfaceNovel methodImprovement of Attenuation Correction in Time-of-Flight PET/MR Imaging with a Positron-Emitting Source
Mollet P, Keereman V, Bini J, Izquierdo-Garcia D, Fayad ZA, Vandenberghe S. Improvement of Attenuation Correction in Time-of-Flight PET/MR Imaging with a Positron-Emitting Source. Journal Of Nuclear Medicine 2014, 55: 329-336. PMID: 24434291, PMCID: PMC4010111, DOI: 10.2967/jnumed.113.125989.Peer-Reviewed Original Research
2013
Preclinical Evaluation of MR Attenuation Correction Versus CT Attenuation Correction on a Sequential Whole-Body MR/PET Scanner
Bini J, Izquierdo-Garcia D, Mateo J, Machac J, Narula J, Fuster V, Fayad ZA. Preclinical Evaluation of MR Attenuation Correction Versus CT Attenuation Correction on a Sequential Whole-Body MR/PET Scanner. Investigative Radiology 2013, 48: 313-322. PMID: 23296082, PMCID: PMC3638002, DOI: 10.1097/rli.0b013e31827a49ba.Peer-Reviewed Original ResearchConceptsPET scannerPositron emission tomography (PET) systemsEmpirical attenuation coefficientsEmission tomography systemAttenuation correctionPET attenuation correctionCTAC methodsTomography systemPhoton attenuationAnimal bedAttenuation coefficientProton densityDirect informationMR/PET imagesCT attenuation correctionLarge bone structuresSUV maximumCoregistered CT imagesAttenuation mapPET imagesQuantitative PETCorrectionScannerMagnetic resonanceTomographic imagesMonitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and 18F-FDG using a combined PET/MR scanner
Millon A, Dickson S, Klink A, Izquierdo-Garcia D, Bini J, Lancelot E, Ballet S, Robert P, de Castro J, Corot C, Fayad Z. Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and 18F-FDG using a combined PET/MR scanner. Atherosclerosis 2013, 228: 339-345. PMID: 23582588, PMCID: PMC4128694, DOI: 10.1016/j.atherosclerosis.2013.03.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, AbdominalAortic DiseasesAtherosclerosisAtorvastatinContrast MediaDextransDisease Models, AnimalDisease ProgressionFluorodeoxyglucose F18Heptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationMagnetic Resonance ImagingMagnetite NanoparticlesPlaque, AtheroscleroticPositron-Emission TomographyPredictive Value of TestsPyrrolesRabbitsRadiographyRadiopharmaceuticalsTime FactorsConceptsFDG-PETPlaque inflammationRegression groupAbdominal aortaAtherosclerotic rabbitsAortic wallMean standard uptake valueStrong FDG uptakeStandard uptake valueContrast-enhanced MRIFDG-PET dataFunctional imaging modalitiesProgression groupBaseline imagingFDG uptakeMR scannerSUVmean valuesUSPIO uptakeAtherosclerotic plaquesMacrophage densityUptake valueEarly changesInflammationRabbit modelDietary changes