Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment
Zhuo Y, Qian T, Wu Y, Seong J, Gong Y, Ma H, Wang Y, Lu S. Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment. Scientific Reports 2015, 5: 12963. PMID: 26261043, PMCID: PMC4531316, DOI: 10.1038/srep12963.Peer-Reviewed Original ResearchMeSH KeywordsCell MovementCell PolarityCell Surface ExtensionsCellular MicroenvironmentEndothelial CellsFluorescence Resonance Energy TransferHumansNeovascularization, PhysiologicSrc-Family KinasesWound HealingConceptsSrc kinase activitySrc activationKinase activityFluorescence resonance energy transfer (FRET)-based biosensorsInitiation of cell migrationNon-polarized cellsCoordinated molecular eventsAutomated computer image analysisMembrane protrusionsCell protrusionsCell polarityProtrusive edgesPolarized cellsMigration of endothelial cellsCell migrationSrcEndothelial cellsMolecular eventsSpatiotemporal coordinationSpatiotemporal controlEndothelial migrationCellsComputer image analysisCell edgeTumor micro-environment