GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation
Trotter S, Kapur J, Anzivino M, Lee K. GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation. Journal Of Neuroscience 2006, 26: 10756-10767. PMID: 17050714, PMCID: PMC6674751, DOI: 10.1523/jneurosci.2323-06.2006.Peer-Reviewed Original ResearchConceptsSpontaneous IPSCsSeizure onsetCortical malformationsPyramidal neuronsAmplitude of spontaneous IPSCsFrequency of spontaneous IPSCsCalcium-binding protein parvalbuminGABAergic synaptic inhibitionHeightened seizure susceptibilityInhibitory GABAergic neurotransmissionPresynaptic GABAergic terminalsGABAergic synaptic transmissionResting membrane potentialPyramidal cell somataHigher input resistanceTish cortexMiniature IPSCsNeocortical malformationsSynaptic inhibitionGABAergic interneuronsGABAergic neurotransmissionSeizure susceptibilityProtein parvalbuminImmunohistochemical assessmentGABAergic terminals