2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDemyelinating DiseasesFemaleHumansMalePositron-Emission TomographyRadiometryRadiopharmaceuticalsTissue DistributionConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal modelsJoint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0
Piccardo A, Albert N, Borgwardt L, Fahey F, Hargrave D, Galldiks N, Jehanno N, Kurch L, Law I, Lim R, Lopci E, Marner L, Morana G, Young Poussaint T, Seghers V, Shulkin B, Warren K, Traub-Weidinger T, Zucchetta P. Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3852-3869. PMID: 35536420, PMCID: PMC9399211, DOI: 10.1007/s00259-022-05817-6.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsChildFluorodeoxyglucose F18GliomaHumansPositron-Emission TomographyRadiopharmaceuticalsConceptsAmino acid positron emission tomographyPositron emission tomographyPaediatric neuro-oncologyEuropean Society for Paediatric Oncology (SIOPENeuro-oncologyLevel of evidenceBrain tumor groupPositron emission tomography imagingEvidence-based recommendationsPaediatric patientsTumor groupResponse assessmentClinician guidelinesPaediatric gliomasBrain gliomasImaging specialistsEmission tomographyRadiolabeled amino acidsConsensus opinionEANMPaediatric oncologyPET radiopharmaceuticalsGliomaNuclear medicineOncology
2019
PET/MR Imaging: Current Updates on Pediatric Applications
Kwatra N, Lim R, Gee M, States L, Vossough A, Lee E. PET/MR Imaging: Current Updates on Pediatric Applications. Magnetic Resonance Imaging Clinics Of North America 2019, 27: 387-407. PMID: 30910104, DOI: 10.1016/j.mric.2019.01.012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolHumansMagnetic Resonance ImagingMultimodal ImagingPediatricsPositron-Emission Tomography
2015
Synergistic role of simultaneous PET/MRI-MRS in soft tissue sarcoma metabolism imaging
Zhang X, Chen Y, Lim R, Huang C, Chebib I, Fakhri G. Synergistic role of simultaneous PET/MRI-MRS in soft tissue sarcoma metabolism imaging. Magnetic Resonance Imaging 2015, 34: 276-279. PMID: 26523656, PMCID: PMC4761342, DOI: 10.1016/j.mri.2015.10.027.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasMagnetic resonance imagingHigh (18)F-FDG uptakeT2 hyperintense massMagnetic resonance spectroscopyNeoadjuvant radiotherapyPathological resultsTumor marginsTissue sarcomasImaging findingsPET/MRI scansPET scansRight thighRadiotherapyNormal tissuesEmission tomographyResonance imagingMetabolite profilesSarcomaPET/MRIChemoRTChemoradiationSynergistic rolePETSurgery
2014
[18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine
Cheney M, Chen Y, Lim R, Winrich B, Grosu A, Trofimov A, Depauw N, Shih H, Schwab J, Hornicek F, DeLaney T. [18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: 1030-1036. PMID: 25539367, PMCID: PMC4280072, DOI: 10.1016/j.ijrobp.2014.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCell HypoxiaChordomaFeasibility StudiesFemaleHumansMaleMiddle AgedMisonidazoleMultimodal ImagingNeoplasm Recurrence, LocalPhotonsPilot ProjectsPositron-Emission TomographyProspective StudiesProton TherapyRadiopharmaceuticalsRadiotherapy DosageRelative Biological EffectivenessSacrococcygeal RegionSpinal NeoplasmsTomography, X-Ray ComputedTumor BurdenConceptsHypoxic subvolumesGross tumor volumeFMISO PET/CTRadiation therapyLocal recurrenceTumor volumeSacrococcygeal spinePositron emission tomography/computed tomographyRT dose escalationStage T2 tumorsEmission tomography/computed tomographyStandardized uptake valueMedian follow-upTreatment of chordomasChanges to treatmentVisualization of tumor hypoxiaDose escalationT2 tumorsTomography/computed tomographyMetastatic diseaseRecurrent chordomaUptake valueClinical characteristicsTumor hypoxiaFollow-upImproving Concordance of MRI and PET/CT Interpretations With Retrospectively Coregistered MRI and PET/CT Data Sets
Wang Y, Lim R, Khawaja R, Blake M. Improving Concordance of MRI and PET/CT Interpretations With Retrospectively Coregistered MRI and PET/CT Data Sets. Current Problems In Diagnostic Radiology 2014, 44: 232-236. PMID: 25745822, DOI: 10.1067/j.cpradiol.2014.11.004.Peer-Reviewed Original ResearchConceptsConcordance of MRIEvidence of metastatic diseaseMRI scansInstitutional review board approvalPelvic MRI scanImaging follow-upInstitutional electronic medical record systemReview board approvalInterpretation of MRIPET/CT interpretationMetastatic diseasePET/computed tomographyDiscordant lesionsMRI findingsRetrospective studyMRI reportsBoard approvalPET/CTFollow-upDiscordant findingsLesion characterizationBone sitesClinical reportsSoftware fusionPairs of scans
2011
Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study
Surti S, Scheuermann J, Fakhri G, Daube-Witherspoon M, Lim R, Abi-Hatem N, Moussallem E, Benard F, Mankoff D, Karp J. Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study. Journal Of Nuclear Medicine 2011, 52: 712-719. PMID: 21498523, PMCID: PMC3104282, DOI: 10.2967/jnumed.110.086678.Peer-Reviewed Original ResearchMeSH KeywordsBody SizeFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedLiver NeoplasmsLung NeoplasmsPositron-Emission TomographyROC CurveTime FactorsWhole Body ImagingConceptsLocalization receiver operating characteristicsTime-of-flight PETLong scan timesArea under the LROC curveScan timeFunction of scan timePatient sizeTime-of-flight (TOFLROC curveLow-uptake lesionsTOF imagesTOF kernelLesion detection taskTOF-PETWhole-body oncologyLesion detection performanceScanner fieldPhantom studyPatient body mass indexProbability of correct localizationLesion detectionSphere dataBody mass indexLarger patientsReceiver operating characteristic
2010
Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging
Hong T, Shammas A, Charron M, Zukotynski K, Drubach L, Lim R. Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging. Pediatric Radiology 2010, 41: 759-768. PMID: 21161205, DOI: 10.1007/s00247-010-1925-y.Peer-Reviewed Original Research
2009
Pediatric FDG PET/CT: Physiologic Uptake, Normal Variants, and Benign Conditions1
Shammas A, Lim R, Charron M. Pediatric FDG PET/CT: Physiologic Uptake, Normal Variants, and Benign Conditions1. RadioGraphics 2009, 29: 1467-86. PMID: 19755606, DOI: 10.1148/rg.295085247.Peer-Reviewed Original ResearchMeSH KeywordsArtifactsChildFluorodeoxyglucose F18HumansImage EnhancementNeoplasmsPositron-Emission TomographyRadiopharmaceuticalsSubtraction TechniqueTomography, X-Ray ComputedConceptsPositron emission tomographyFDG uptakeBenign lesionsPhysiological uptakeIncreased (18)F-FDG uptakeFDG-PET/CT studiesPhysiological variantsHead and neckAssociated with pitfallsUrinary collecting systemPediatric oncology patientsPET/CT studiesFollow-up studyPET/computed tomographicBone marrowImprove patient treatmentOncology patientsNormal variantsPET image interpretationEmission tomographyPatient treatmentAttenuation correctionAdipose tissueBrown adipose tissueGastrointestinal tract
2007
Early Experience With Fluorine-18 Sodium Fluoride Bone PET in Young Patients With Back Pain
Lim R, Fahey F, Drubach L, Connolly L, Treves S. Early Experience With Fluorine-18 Sodium Fluoride Bone PET in Young Patients With Back Pain. Journal Of Pediatric Orthopaedics 2007, 27: 277-282. PMID: 17414009, DOI: 10.1097/bpo.0b013e31803409ba.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBack PainChildChild, PreschoolDiagnosis, DifferentialFemaleFluorine RadioisotopesHumansMalePositron-Emission TomographySodium FluorideConceptsPositron emission tomographyBack painYounger patientsPotential sources of back painSource of back painFluorine-18Evaluating young patientsRadiation dosimetryNaF PET scanEnhanced patient throughputPET scansApophyseal injuriesPainTechnetium-99Tracer administrationPatientsRadiation doseSkeletal abnormalitiesPET acquisitionEmission tomographySodium fluorideScintigraphyNinety-fourPatient throughputDosimetry