2012
In vivo MRS and histochemistry of status epilepticus‐induced hippocampal pathology in a juvenile model of temporal lobe epilepsy
van der Hel W, van Eijsden P, Bos IW, de Graaf R, Behar KL, van Nieuwenhuizen O, de Graan P, Braun KP. In vivo MRS and histochemistry of status epilepticus‐induced hippocampal pathology in a juvenile model of temporal lobe epilepsy. NMR In Biomedicine 2012, 26: 132-140. PMID: 22806932, DOI: 10.1002/nbm.2828.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyStatus epilepticusSynthase immunoreactivityNeuronal lossHippocampal pathologyLobe epilepsyDevelopment of TLECholine-containing compound concentrationsChildhood status epilepticusPre-epileptic stateSpontaneous recurrent seizuresVivo MRSJuvenile rat modelHippocampal injuryChronic epilepsyRecurrent seizuresSpontaneous seizuresNeurotransmitter imbalanceParvalbumin immunoreactivityVivo immunohistochemistryInhibitory neurotransmissionΓ-aminobutyric acidEpileptogenic processMRS findingsNeuronal death
2011
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans
Rothman DL, De Feyter HM, de Graaf R, Mason GF, Behar KL. 13C MRS studies of neuroenergetics and neurotransmitter cycling in humans. NMR In Biomedicine 2011, 24: 943-957. PMID: 21882281, PMCID: PMC3651027, DOI: 10.1002/nbm.1772.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNeurotransmitter cyclingMRS studiesHigh neuronal activityHuman brain diseasesOnly noninvasive methodBrain metabolismGlutamate neurotransmissionNeuronal activityPsychiatric diseasesNeuronal functionBrain diseasesBrain functionClinical researchNeuroenergeticsNoninvasive methodMRSMRS measurementsHuman researchDiseaseBrain statesRecent findingsImportant new informationHumansMetabolic pathwaysNeurotransmission
2003
Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity
PATEL AB, DE GRAAF R, MASON GF, ROTHMAN DL, SHULMAN RG, BEHAR KL. Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity. Annals Of The New York Academy Of Sciences 2003, 1003: 452-453. PMID: 14684486, DOI: 10.1196/annals.1300.050.Peer-Reviewed Original Research