1999
Effects of Hypoxia-Ischemia and Inhibition of Nitric Oxide Synthase on Cerebral Energy Metabolism in Newborn Piglets
Groenendaal F, De Graaf R, Van Vliet G, Nicolay K. Effects of Hypoxia-Ischemia and Inhibition of Nitric Oxide Synthase on Cerebral Energy Metabolism in Newborn Piglets. Pediatric Research 1999, 45: 827-833. PMID: 10367773, DOI: 10.1203/00006450-199906000-00008.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseCerebral energy metabolismHypoxia-ischemiaCerebral hypoxia-ischemiaN-acetylaspartate ratiosOxide synthaseBaseline valuesNewborn pigletsInorganic phosphate ratioHypoxia groupCerebral energy statusEnergy metabolismSaline 1 hEffect of inhibitionBilateral occlusionNω-nitroCarotid arteryAcetylaspartate ratioL-arginineOld pigletsPhosphate ratioBaseline periodReperfusionNNLAPigletsChanges in the Diffusion of Water and Intracellular Metabolites After Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain
Dijkhuizen R, de Graaf R, Tulleken K, Nicolay K. Changes in the Diffusion of Water and Intracellular Metabolites After Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 341-349. PMID: 10078886, DOI: 10.1097/00004647-199903000-00012.Peer-Reviewed Original ResearchConceptsNeonatal rat brainMetabolite apparent diffusion coefficientsGlobal ischemiaApparent diffusion coefficientADC dropExcitotoxic injuryRat brainN-methyl-D-aspartate (NMDA) injectionAcute cerebral ischemiaDiffusion-weighted magnetic resonance imagingBrain metabolite levelsMagnetic resonance imagingBrain temperature changesTissue deoxygenationCerebral ischemiaNMDA injectionContralateral valuesCytotoxic edemaMetabolites taurineBrain tissue waterN-acetylaspartateIschemiaWater apparent diffusion coefficientResonance imagingEarly alterations
1998
Adiabatic water suppression using frequency selective excitation
de Graaf R, Nicolay K. Adiabatic water suppression using frequency selective excitation. Magnetic Resonance In Medicine 1998, 40: 690-696. PMID: 9797151, DOI: 10.1002/mrm.1910400508.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBody WaterBrainMagnetic Resonance ImagingModels, TheoreticalRatsSensitivity and Specificity