2024
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Mevenkamp J, Bruls Y, Mancilla R, Grevendonk L, Wildberger J, Brouwers K, Hesselink M, Schrauwen P, Hoeks J, Houtkooper R, Buitinga M, de Graaf R, Lindeboom L, Schrauwen-Hinderling V. Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T. Nature Communications 2024, 15: 9159. PMID: 39443469, PMCID: PMC11499639, DOI: 10.1038/s41467-024-53292-4.Peer-Reviewed Original ResearchConceptsPhysically active older adultsActive older adultsMetabolic healthHuman skeletal musclePhosphorous magnetic resonance spectroscopySedentary individualsOlder adultsStimulate mitochondrial biogenesisHealthSkeletal muscleMitochondrial biogenesisNAD+Physiological decreaseNADH contentNADHQuantify NADHClinical 3Magnetic resonance spectroscopy techniquesMR sequencesAdultsMeasurement reproducibility
2023
Design and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner
Theilenberg S, Shang Y, Ghazouani J, Kumaragamage C, Nixon T, McIntyre S, Vaughan J, Parkinson B, Garwood M, de Graaf R, Juchem C. Design and realization of a multi‐coil array for B0 field control in a compact 1.5T head‐only MRI scanner. Magnetic Resonance In Medicine 2023, 90: 1228-1241. PMID: 37145035, PMCID: PMC10330274, DOI: 10.1002/mrm.29692.Peer-Reviewed Original ResearchConceptsMulti-coil arraysMC arraysDuty cycleGeneration capabilityT headNonlinear magnetic fieldHigh duty cycleThermal behaviorBench testingField controlRamp timeResidual imperfectionField generationScanner designMagnetic fieldMC hardwareLinear gradientMRI scannerArrayCapabilityDesignHardwareImage encodingFieldMagnets
2022
Deuterium metabolic imaging of the human brain in vivo at 7 T
Roig E, De Feyter HM, Nixon TW, Ruhm L, Nikulin AV, Scheffler K, Avdievich NI, Henning A, de Graaf R. Deuterium metabolic imaging of the human brain in vivo at 7 T. Magnetic Resonance In Medicine 2022, 89: 29-39. PMID: 36063499, PMCID: PMC9756916, DOI: 10.1002/mrm.29439.Peer-Reviewed Original ResearchInterleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo
Liu Y, De Feyter HM, Fulbright RK, McIntyre S, Nixon TW, de Graaf R. Interleaved fluid‐attenuated inversion recovery (FLAIR) MRI and deuterium metabolic imaging (DMI) on human brain in vivo. Magnetic Resonance In Medicine 2022, 88: 28-37. PMID: 35225375, PMCID: PMC9924309, DOI: 10.1002/mrm.29196.Peer-Reviewed Original Research
2020
Water and lipid suppression techniques for advanced 1H MRS and MRSI of the human brain: Experts' consensus recommendations
Tkáč I, Deelchand D, Dreher W, Hetherington H, Kreis R, Kumaragamage C, Považan M, Spielman DM, Strasser B, de Graaf R. Water and lipid suppression techniques for advanced 1H MRS and MRSI of the human brain: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4459. PMID: 33327042, PMCID: PMC8569948, DOI: 10.1002/nbm.4459.Peer-Reviewed Original ResearchContribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations
Cudalbu C, Behar KL, Bhattacharyya PK, Bogner W, Borbath T, de Graaf R, Gruetter R, Henning A, Juchem C, Kreis R, Lee P, Lei H, Marjańska M, Mekle R, Murali‐Manohar S, Považan M, Rackayová V, Simicic D, Slotboom J, Soher BJ, Starčuk Z, Starčuková J, Tkáč I, Williams S, Wilson M, Wright AM, Xin L, Mlynárik V. Contribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4393. PMID: 33236818, PMCID: PMC10072289, DOI: 10.1002/nbm.4393.Peer-Reviewed Original ResearchECLIPSE utilizing gradient‐modulated offset‐independent adiabaticity (GOIA) pulses for highly selective human brain proton MRSI
Kumaragamage C, De Feyter HM, Brown P, McIntyre S, Nixon TW, de Graaf R. ECLIPSE utilizing gradient‐modulated offset‐independent adiabaticity (GOIA) pulses for highly selective human brain proton MRSI. NMR In Biomedicine 2020, 34: e4415. PMID: 33001485, PMCID: PMC9472321, DOI: 10.1002/nbm.4415.Peer-Reviewed Original ResearchSpectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations
Choi I, Andronesi O, Barker P, Bogner W, Edden R, Kaiser L, Lee P, Marjańska M, Terpstra M, de Graaf R. Spectral editing in 1H magnetic resonance spectroscopy: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4411. PMID: 32946145, PMCID: PMC8557623, DOI: 10.1002/nbm.4411.Peer-Reviewed Original ResearchConceptsSpectral editingIn vivo<sup>1</sup>H MRS, paMulticenter clinical trialSpectral fittingExpert consensus recommendationsD-2-hydroxyglutarateJ-couplingG-aminobutyric acidH-MRSFrequency driftClinical trialsSignal overlapConsensus recommendationsMagnetic resonance spectroscopyMetabolite signalsResonance spectroscopyResonanceExpert recommendationsSequence parametersB0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations
Juchem C, Cudalbu C, de Graaf R, Gruetter R, Henning A, Hetherington H, Boer V. B0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4350. PMID: 32596978, DOI: 10.1002/nbm.4350.Peer-Reviewed Original ResearchDynamic multicoil technique (DYNAMITE) MRI on human brain
Juchem C, Theilenberg S, Kumaragamage C, Mullen M, DelaBarre L, Adriany G, Brown PB, McIntyre S, Nixon TW, Garwood M, de Graaf R. Dynamic multicoil technique (DYNAMITE) MRI on human brain. Magnetic Resonance In Medicine 2020, 84: 2953-2963. PMID: 32544274, PMCID: PMC8168279, DOI: 10.1002/mrm.28323.Peer-Reviewed Original ResearchConceptsGradient coilsConventional gradient coilsField controlMagnetic field gradientImage fidelityShim systemBiot-Savart lawFirst realizationCylindrical surfaceCoil technologyGradient technologyImage distortion correctionGradient fieldGradient errorsField imperfectionsHuman headCoilGeometric deformationMR environmentField gradientLinear xDistortion correctionResolution phantomSpatial encodingNumerical integrationIn vivo MRS measurement of 2‐hydroxyglutarate in patient‐derived IDH‐mutant xenograft mouse models versus glioma patients
Tiwari V, Mashimo T, An Z, Vemireddy V, Piccirillo S, Askari P, Hulsey K, Zhang S, de Graaf R, Patel T, Pan E, Mickey B, Maher E, Bachoo R, Choi C. In vivo MRS measurement of 2‐hydroxyglutarate in patient‐derived IDH‐mutant xenograft mouse models versus glioma patients. Magnetic Resonance In Medicine 2020, 84: 1152-1160. PMID: 32003035, PMCID: PMC7263951, DOI: 10.1002/mrm.28183.Peer-Reviewed Original ResearchConceptsPatient-derived xenograftsPatient-derived xenograft micePreclinical modelsGlioma patientsPatient-derived xenograft tumorsPatient-derived xenograft modelsDetection of 2HGIDH1 R132H mutationShort-TE MRSXenograft mouse modelMutant gliomasR132H mutationIDH-mutantIn vivo MRS measurementsMouse modelPhantom analysisMetabolic reprogrammingPatientsMetabolite levelsGliomaMiceMetabolic fingerprintsPRESS sequenceIsocitrate dehydrogenaseMRS methods
2019
On the magnetic field dependence of deuterium metabolic imaging
de Graaf R, Hendriks AD, Klomp DWJ, Kumaragamage C, Welting D, de Castro C, Brown PB, McIntyre S, Nixon TW, Prompers JJ, De Feyter HM. On the magnetic field dependence of deuterium metabolic imaging. NMR In Biomedicine 2019, 33: e4235. PMID: 31879985, PMCID: PMC7141779, DOI: 10.1002/nbm.4235.Peer-Reviewed Original ResearchRobust outer volume suppression utilizing elliptical pulsed second order fields (ECLIPSE) for human brain proton MRSI
Kumaragamage C, De Feyter HM, Brown P, McIntyre S, Nixon TW, de Graaf R. Robust outer volume suppression utilizing elliptical pulsed second order fields (ECLIPSE) for human brain proton MRSI. Magnetic Resonance In Medicine 2019, 83: 1539-1552. PMID: 31742799, PMCID: PMC6982600, DOI: 10.1002/mrm.28047.Peer-Reviewed Original ResearchIn vivo 13C and 1H‐[13C] MRS studies of neuroenergetics and neurotransmitter cycling, applications to neurological and psychiatric disease and brain cancer
Rothman DL, de Graaf R, Hyder F, Mason GF, Behar KL, De Feyter HM. In vivo 13C and 1H‐[13C] MRS studies of neuroenergetics and neurotransmitter cycling, applications to neurological and psychiatric disease and brain cancer. NMR In Biomedicine 2019, 32: e4172. PMID: 31478594, DOI: 10.1002/nbm.4172.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances 2018, 4: eaat7314. PMID: 30140744, PMCID: PMC6105304, DOI: 10.1126/sciadv.aat7314.Peer-Reviewed Original ResearchConceptsOral intakeMetabolic imagingGlucose uptakeHigh-grade brain tumorsRat glioma modelPositron emission tomography (PET) detectionSimilar metabolic patternMetabolic imaging techniquesDeuterium metabolic imagingHigher glucose uptakeGlucose analog 2FDG-PETF-fluoroIntravenous infusionBrain tumorsGlioma modelGlucose metabolismNormal brainTomography detectionAnimal modelsMagnetic resonance spectroscopicTumor tissueHuman liverMetabolic patternsNoninvasive approachElliptical localization with pulsed second‐order fields (ECLIPSE) for robust lipid suppression in proton MRSI
de Graaf R, Brown PB, De Feyter HM, McIntyre S, Nixon TW. Elliptical localization with pulsed second‐order fields (ECLIPSE) for robust lipid suppression in proton MRSI. NMR In Biomedicine 2018, 31: e3949. PMID: 29985532, PMCID: PMC6108906, DOI: 10.1002/nbm.3949.Peer-Reviewed Original Research
2017
Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex
De Feyter H, Herzog RI, Steensma BR, Klomp DWJ, Brown PB, Mason GF, Rothman DL, de Graaf R. Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex. Magnetic Resonance In Medicine 2017, 80: 11-20. PMID: 29134686, PMCID: PMC5876108, DOI: 10.1002/mrm.27003.Peer-Reviewed Original ResearchMeasurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing
Lindeboom L, de Graaf R. Measurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing. Magnetic Resonance In Medicine 2017, 79: 619-627. PMID: 28474367, DOI: 10.1002/mrm.26740.Peer-Reviewed Original ResearchConceptsAdipose tissueProton magnetic resonance spectroscopySkeletal muscleH-MRSAccumulation of triglyceridesInvasive biopsyMetabolic derangementsEctopic fatInsulin resistanceCardiovascular diseaseMetabolic diseasesMEGA-sLASER sequenceIn vivoNonadipose tissuesLipid resonancesSpectral editingPolyunsaturated fatty acidsHuman skeletal muscleMagnetic resonance spectroscopyLipid storesLipid compositionAdiposeSpectral resolutionTissuePhantom experiments
2016
The public multi‐coil information (PUMCIN) policy
Juchem C, de Graaf R. The public multi‐coil information (PUMCIN) policy. Magnetic Resonance In Medicine 2016, 78: 2042-2047. PMID: 27905145, PMCID: PMC5453847, DOI: 10.1002/mrm.26558.Peer-Reviewed Original ResearchDetection of cerebral NAD+ in humans at 7T
de Graaf R, De Feyter H, Brown PB, Nixon TW, Rothman DL, Behar KL. Detection of cerebral NAD+ in humans at 7T. Magnetic Resonance In Medicine 2016, 78: 828-835. PMID: 27670385, PMCID: PMC5366282, DOI: 10.1002/mrm.26465.Peer-Reviewed Original Research