2023
In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging
Meerwaldt A, Straathof M, Oosterveld W, van Heijningen C, van Leent M, Toner Y, Munitz J, Teunissen A, Daemen C, van der Toorn A, van Vliet G, van Tilborg G, De Feyter H, de Graaf R, Hol E, Mulder W, Dijkhuizen R. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 778-790. PMID: 36606595, PMCID: PMC10108187, DOI: 10.1177/0271678x221148970.Peer-Reviewed Original ResearchConceptsTransient middle cerebral artery occlusionPositron emission tomographyGlucose metabolismPost-ischemic brain tissueMiddle cerebral artery occlusionFDG positron emission tomographyFluorodeoxyglucose positron emission tomographyMetabolic imagingSignificant glial activationAcute ischemic strokeCerebral artery occlusionCerebral energy metabolismDeuterium metabolic imagingActive glucose metabolismGlial activationRecanalization therapyArtery occlusionIschemic strokeStroke severityCerebral perfusionC57BL/6 micePoor outcomeElevated lactate productionPathophysiological changesBaseline values
2022
Deuterium metabolic imaging of the human brain in vivo at 7 T
Roig E, De Feyter HM, Nixon TW, Ruhm L, Nikulin AV, Scheffler K, Avdievich NI, Henning A, de Graaf R. Deuterium metabolic imaging of the human brain in vivo at 7 T. Magnetic Resonance In Medicine 2022, 89: 29-39. PMID: 36063499, PMCID: PMC9756916, DOI: 10.1002/mrm.29439.Peer-Reviewed Original Research
2021
NMR visibility of deuterium‐labeled liver glycogen in vivo
De Feyter HM, Thomas MA, Behar KL, de Graaf R. NMR visibility of deuterium‐labeled liver glycogen in vivo. Magnetic Resonance In Medicine 2021, 86: 62-68. PMID: 33590529, PMCID: PMC8005460, DOI: 10.1002/mrm.28717.Peer-Reviewed Original Research
2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances 2018, 4: eaat7314. PMID: 30140744, PMCID: PMC6105304, DOI: 10.1126/sciadv.aat7314.Peer-Reviewed Original ResearchConceptsOral intakeMetabolic imagingGlucose uptakeHigh-grade brain tumorsRat glioma modelPositron emission tomography (PET) detectionSimilar metabolic patternMetabolic imaging techniquesDeuterium metabolic imagingHigher glucose uptakeGlucose analog 2FDG-PETF-fluoroIntravenous infusionBrain tumorsGlioma modelGlucose metabolismNormal brainTomography detectionAnimal modelsMagnetic resonance spectroscopicTumor tissueHuman liverMetabolic patternsNoninvasive approachMinimum echo time PRESS‐based proton observed carbon edited (POCE) MRS in rat brain using simultaneous editing and localization pulses
Kumaragamage C, Madularu D, Mathieu AP, Lupinsky D, de Graaf R, Near J. Minimum echo time PRESS‐based proton observed carbon edited (POCE) MRS in rat brain using simultaneous editing and localization pulses. Magnetic Resonance In Medicine 2018, 80: 1279-1288. PMID: 29427395, DOI: 10.1002/mrm.27119.Peer-Reviewed Original Research
2003
Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity
PATEL AB, DE GRAAF R, MASON GF, ROTHMAN DL, SHULMAN RG, BEHAR KL. Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity. Annals Of The New York Academy Of Sciences 2003, 1003: 452-453. PMID: 14684486, DOI: 10.1196/annals.1300.050.Peer-Reviewed Original Research
2001
Differentiation of Glucose Transport in Human Brain Gray and White Matter
de Graaf R, Pan J, Telang F, Lee J, Brown P, Novotny E, Hetherington H, Rothman D. Differentiation of Glucose Transport in Human Brain Gray and White Matter. Cerebrovascular And Brain Metabolism Reviews 2001, 21: 483-492. PMID: 11333358, DOI: 10.1097/00004647-200105000-00002.Peer-Reviewed Original ResearchConceptsKinetic transport modelSpectroscopic measurementsStandard modelTransport modelHuman brain grayNuclear magnetic resonance spectroscopic measurementsStandard transport modelMagnetic resonance spectroscopic measurementsThreefold lower rateNuclear magnetic resonance spectroscopyResonance spectroscopyHuman brain gray matterMagnetic resonance spectroscopyMatterVolume compositionSpectroscopyWhite matter levelsMeasurements
1999
Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain
Dijkhuizen R, de Graaf R, Garwood M, Tulleken K, Nicolay K. Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 376-379. PMID: 10197507, DOI: 10.1097/00004647-199904000-00003.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaCerebral ischemiaFocal ischemic rat brainAcute focal cerebral ischemiaIschemic rat brainMagnetic resonance spectroscopic imaging techniquesTherapeutic intervention strategiesBorderzone areasIschemic penumbraIschemic coreSalvageable penumbraLactate formationRat modelRat brainEarly identificationIschemiaViable tissueIntervention strategiesInfusionPenumbraImaging techniquesLactateEnrichment of lactate