2024
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Mevenkamp J, Bruls Y, Mancilla R, Grevendonk L, Wildberger J, Brouwers K, Hesselink M, Schrauwen P, Hoeks J, Houtkooper R, Buitinga M, de Graaf R, Lindeboom L, Schrauwen-Hinderling V. Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T. Nature Communications 2024, 15: 9159. PMID: 39443469, PMCID: PMC11499639, DOI: 10.1038/s41467-024-53292-4.Peer-Reviewed Original ResearchConceptsPhysically active older adultsActive older adultsMetabolic healthHuman skeletal musclePhosphorous magnetic resonance spectroscopySedentary individualsOlder adultsStimulate mitochondrial biogenesisHealthSkeletal muscleMitochondrial biogenesisNAD+Physiological decreaseNADH contentNADHQuantify NADHClinical 3Magnetic resonance spectroscopy techniquesMR sequencesAdultsMeasurement reproducibility
2020
Contribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations
Cudalbu C, Behar KL, Bhattacharyya PK, Bogner W, Borbath T, de Graaf R, Gruetter R, Henning A, Juchem C, Kreis R, Lee P, Lei H, Marjańska M, Mekle R, Murali‐Manohar S, Považan M, Rackayová V, Simicic D, Slotboom J, Soher BJ, Starčuk Z, Starčuková J, Tkáč I, Williams S, Wilson M, Wright AM, Xin L, Mlynárik V. Contribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations. NMR In Biomedicine 2020, 34: e4393. PMID: 33236818, PMCID: PMC10072289, DOI: 10.1002/nbm.4393.Peer-Reviewed Original Research
2017
Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex
De Feyter H, Herzog RI, Steensma BR, Klomp DWJ, Brown PB, Mason GF, Rothman DL, de Graaf R. Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex. Magnetic Resonance In Medicine 2017, 80: 11-20. PMID: 29134686, PMCID: PMC5876108, DOI: 10.1002/mrm.27003.Peer-Reviewed Original ResearchMeasurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing
Lindeboom L, de Graaf R. Measurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing. Magnetic Resonance In Medicine 2017, 79: 619-627. PMID: 28474367, DOI: 10.1002/mrm.26740.Peer-Reviewed Original ResearchConceptsAdipose tissueProton magnetic resonance spectroscopySkeletal muscleH-MRSAccumulation of triglyceridesInvasive biopsyMetabolic derangementsEctopic fatInsulin resistanceCardiovascular diseaseMetabolic diseasesMEGA-sLASER sequenceIn vivoNonadipose tissuesLipid resonancesSpectral editingPolyunsaturated fatty acidsHuman skeletal muscleMagnetic resonance spectroscopyLipid storesLipid compositionAdiposeSpectral resolutionTissuePhantom experiments
2016
Detection of cerebral NAD+ in humans at 7T
de Graaf R, De Feyter H, Brown PB, Nixon TW, Rothman DL, Behar KL. Detection of cerebral NAD+ in humans at 7T. Magnetic Resonance In Medicine 2016, 78: 828-835. PMID: 27670385, PMCID: PMC5366282, DOI: 10.1002/mrm.26465.Peer-Reviewed Original Research
2013
Intramolecular zero‐quantum‐coherence 2D NMR spectroscopy of lipids in the human breast at 7 T
de Graaf R, Klomp D, Luijten P, Boer V. Intramolecular zero‐quantum‐coherence 2D NMR spectroscopy of lipids in the human breast at 7 T. Magnetic Resonance In Medicine 2013, 71: 451-457. PMID: 23468435, DOI: 10.1002/mrm.24701.Peer-Reviewed Original ResearchConceptsMagnetic field homogeneityZero-quantum coherencesMagnetic field inhomogeneityField homogeneityField inhomogeneityNavigator echo correctionHuman breastEcho correctionSusceptible boundariesSpectra in vivoHuman breast tissueLipid profileInhomogeneityBreast tissueBreastIn vivoIn vitroLipid signalingSpectraNMR spectraMRSSubjectsNMR
2011
Dynamic multi-coil shimming of the human brain at 7T
Juchem C, Nixon TW, McIntyre S, Boer VO, Rothman DL, de Graaf RA. Dynamic multi-coil shimming of the human brain at 7T. Journal Of Magnetic Resonance 2011, 212: 280-288. PMID: 21824794, PMCID: PMC3183127, DOI: 10.1016/j.jmr.2011.07.005.Peer-Reviewed Original Research
2001
Differentiation of Glucose Transport in Human Brain Gray and White Matter
de Graaf R, Pan J, Telang F, Lee J, Brown P, Novotny E, Hetherington H, Rothman D. Differentiation of Glucose Transport in Human Brain Gray and White Matter. Cerebrovascular And Brain Metabolism Reviews 2001, 21: 483-492. PMID: 11333358, DOI: 10.1097/00004647-200105000-00002.Peer-Reviewed Original ResearchConceptsKinetic transport modelSpectroscopic measurementsStandard modelTransport modelHuman brain grayNuclear magnetic resonance spectroscopic measurementsStandard transport modelMagnetic resonance spectroscopic measurementsThreefold lower rateNuclear magnetic resonance spectroscopyResonance spectroscopyHuman brain gray matterMagnetic resonance spectroscopyMatterVolume compositionSpectroscopyWhite matter levelsMeasurements