2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances 2018, 4: eaat7314. PMID: 30140744, PMCID: PMC6105304, DOI: 10.1126/sciadv.aat7314.Peer-Reviewed Original ResearchConceptsOral intakeMetabolic imagingGlucose uptakeHigh-grade brain tumorsRat glioma modelPositron emission tomography (PET) detectionSimilar metabolic patternMetabolic imaging techniquesDeuterium metabolic imagingHigher glucose uptakeGlucose analog 2FDG-PETF-fluoroIntravenous infusionBrain tumorsGlioma modelGlucose metabolismNormal brainTomography detectionAnimal modelsMagnetic resonance spectroscopicTumor tissueHuman liverMetabolic patternsNoninvasive approach
2017
Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex
De Feyter H, Herzog RI, Steensma BR, Klomp DWJ, Brown PB, Mason GF, Rothman DL, de Graaf R. Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex. Magnetic Resonance In Medicine 2017, 80: 11-20. PMID: 29134686, PMCID: PMC5876108, DOI: 10.1002/mrm.27003.Peer-Reviewed Original Research
2001
Single‐shot diffusion trace 1H NMR spectroscopy
de Graaf R, Braun K, Nicolay K. Single‐shot diffusion trace 1H NMR spectroscopy. Magnetic Resonance In Medicine 2001, 45: 741-748. PMID: 11323799, DOI: 10.1002/mrm.1101.Peer-Reviewed Original Research
1999
Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain
Dijkhuizen R, de Graaf R, Garwood M, Tulleken K, Nicolay K. Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 376-379. PMID: 10197507, DOI: 10.1097/00004647-199904000-00003.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaCerebral ischemiaFocal ischemic rat brainAcute focal cerebral ischemiaIschemic rat brainMagnetic resonance spectroscopic imaging techniquesTherapeutic intervention strategiesBorderzone areasIschemic penumbraIschemic coreSalvageable penumbraLactate formationRat modelRat brainEarly identificationIschemiaViable tissueIntervention strategiesInfusionPenumbraImaging techniquesLactateEnrichment of lactate