1999
Cerebral Metabolism Measured Using Proton and Phosphorous Magnetic Resonance Spectroscopy (MRS) Following Hypoxia Ischemia (HI) and Administration of Allopurinol (ALLO) and Deferoxamine (DFO)
Peeters C, Van Den Tweel E, De Graaf R, Braun K, Nicolay K, Van Bel F, Groenendaal F. Cerebral Metabolism Measured Using Proton and Phosphorous Magnetic Resonance Spectroscopy (MRS) Following Hypoxia Ischemia (HI) and Administration of Allopurinol (ALLO) and Deferoxamine (DFO). Pediatric Research 1999, 45: 345-345. DOI: 10.1203/00006450-199904020-02053.Peer-Reviewed Original ResearchSpatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain
Dijkhuizen R, de Graaf R, Garwood M, Tulleken K, Nicolay K. Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 376-379. PMID: 10197507, DOI: 10.1097/00004647-199904000-00003.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaCerebral ischemiaFocal ischemic rat brainAcute focal cerebral ischemiaIschemic rat brainMagnetic resonance spectroscopic imaging techniquesTherapeutic intervention strategiesBorderzone areasIschemic penumbraIschemic coreSalvageable penumbraLactate formationRat modelRat brainEarly identificationIschemiaViable tissueIntervention strategiesInfusionPenumbraImaging techniquesLactateEnrichment of lactateChanges in the Diffusion of Water and Intracellular Metabolites After Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain
Dijkhuizen R, de Graaf R, Tulleken K, Nicolay K. Changes in the Diffusion of Water and Intracellular Metabolites After Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 341-349. PMID: 10078886, DOI: 10.1097/00004647-199903000-00012.Peer-Reviewed Original ResearchConceptsNeonatal rat brainMetabolite apparent diffusion coefficientsGlobal ischemiaApparent diffusion coefficientADC dropExcitotoxic injuryRat brainN-methyl-D-aspartate (NMDA) injectionAcute cerebral ischemiaDiffusion-weighted magnetic resonance imagingBrain metabolite levelsMagnetic resonance imagingBrain temperature changesTissue deoxygenationCerebral ischemiaNMDA injectionContralateral valuesCytotoxic edemaMetabolites taurineBrain tissue waterN-acetylaspartateIschemiaWater apparent diffusion coefficientResonance imagingEarly alterations
1997
Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study
Braun K, Dijkhuizen R, de Graaf R, Nicolay K, Vandertop W, Gooskens R, Tulleken K. Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study. Brain Research 1997, 757: 295-298. PMID: 9200761, DOI: 10.1016/s0006-8993(97)00345-4.Peer-Reviewed Original Research