1999
Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain
Dijkhuizen R, de Graaf R, Garwood M, Tulleken K, Nicolay K. Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 376-379. PMID: 10197507, DOI: 10.1097/00004647-199904000-00003.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaCerebral ischemiaFocal ischemic rat brainAcute focal cerebral ischemiaIschemic rat brainMagnetic resonance spectroscopic imaging techniquesTherapeutic intervention strategiesBorderzone areasIschemic penumbraIschemic coreSalvageable penumbraLactate formationRat modelRat brainEarly identificationIschemiaViable tissueIntervention strategiesInfusionPenumbraImaging techniquesLactateEnrichment of lactateChanges in the Diffusion of Water and Intracellular Metabolites After Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain
Dijkhuizen R, de Graaf R, Tulleken K, Nicolay K. Changes in the Diffusion of Water and Intracellular Metabolites After Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 341-349. PMID: 10078886, DOI: 10.1097/00004647-199903000-00012.Peer-Reviewed Original ResearchConceptsNeonatal rat brainMetabolite apparent diffusion coefficientsGlobal ischemiaApparent diffusion coefficientADC dropExcitotoxic injuryRat brainN-methyl-D-aspartate (NMDA) injectionAcute cerebral ischemiaDiffusion-weighted magnetic resonance imagingBrain metabolite levelsMagnetic resonance imagingBrain temperature changesTissue deoxygenationCerebral ischemiaNMDA injectionContralateral valuesCytotoxic edemaMetabolites taurineBrain tissue waterN-acetylaspartateIschemiaWater apparent diffusion coefficientResonance imagingEarly alterations
1998
In vivo 1H MR spectroscopic imaging and difusion weighted mri in experimental hydrocephalus
Braun K, de Graaf R, Vandertop W, Gooskens R, Tulleken K, Nicolay K. In vivo 1H MR spectroscopic imaging and difusion weighted mri in experimental hydrocephalus. Magnetic Resonance In Medicine 1998, 40: 832-839. PMID: 9840827, DOI: 10.1002/mrm.1910400608.Peer-Reviewed Original ResearchConceptsMR spectroscopic imagingExperimental hydrocephalusApparent diffusion coefficientInjection of kaolinIschemic metabolic changesWhite matter edemaDegree of ventriculomegalyHigher lactate levelsGray matter regionsProgressive ventriculomegalyCerebral edemaCerebral ischemiaVentricular enlargementHydrocephalic ratsKaolin injectionRat modelAccumulation of lactateDifferent time coursesLactate levelsCerebrospinal fluidCisterna magnaVentricular expansionHydrocephalusWhole brainSpectroscopic imaging
1997
Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study
Braun K, Dijkhuizen R, de Graaf R, Nicolay K, Vandertop W, Gooskens R, Tulleken K. Cerebral ischemia and white matter edema in experimental hydrocephalus: a combined in vivo MRI and MRS study. Brain Research 1997, 757: 295-298. PMID: 9200761, DOI: 10.1016/s0006-8993(97)00345-4.Peer-Reviewed Original Research