1999
Bolus Injection Versus Slow Infusion of [15O]Water for Positron Emission Tomography Activation Studies
Beason-Held L, Desmond R, Herscovitch P, Carson R. Bolus Injection Versus Slow Infusion of [15O]Water for Positron Emission Tomography Activation Studies. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 843-852. PMID: 10458591, DOI: 10.1097/00004647-199908000-00003.Peer-Reviewed Original ResearchAdultBrainBrain MappingCerebrovascular CirculationFaceFemaleHumansImage Processing, Computer-AssistedInfusions, IntravenousInjections, IntravenousMemory, Short-TermModels, CardiovascularModels, NeurologicalOxygen RadioisotopesPattern Recognition, VisualReference ValuesRegional Blood FlowSensitivity and SpecificityTomography, Emission-ComputedWater
1997
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
Breier A, Su T, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2569-2574. PMID: 9122236, PMCID: PMC20129, DOI: 10.1073/pnas.94.6.2569.Peer-Reviewed Original ResearchConceptsSynaptic dopamine concentrationsDopamine concentrationsDopamine outflowDopamine levelsStriatal extracellular dopamine levelsBinding reductionPositron emission tomography radioligandExtracellular dopamine levelsSynaptic dopamine levelsAmphetamine-induced changesNonhuman primate studiesPositron emission tomography (PET) methodDopamine overactivityPatients elevationNovel brain imaging methodVivo microdialysisAmphetamine doseDopamine receptorsClinical studiesDopamine releasePreclinical studiesHealthy volunteersBrain imaging methodsDopamine increasesTomography radioligand