2015
Test–Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the κ Opioid Receptor
Naganawa M, Zheng MQ, Henry S, Nabulsi N, Lin SF, Ropchan J, Labaree D, Najafzadeh S, Kapinos M, Tauscher J, Neumeister A, Carson RE, Huang Y. Test–Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the κ Opioid Receptor. Journal Of Nuclear Medicine 2015, 56: 243-248. PMID: 25593119, PMCID: PMC4322754, DOI: 10.2967/jnumed.114.147975.Peer-Reviewed Original ResearchConceptsTest-retest variabilityOpioid receptorsOutcome measuresAbsolute test-retest variabilityMultilinear analysis 1Healthy human subjectsSuitable reference regionTest-retest reproducibilityIntraclass correlation coefficientAntagonist radiotracersHealthy subjectsLY2795050PET scansBrain regionsDistribution volumePET radioligandTest-retest performancePET studiesArterial input functionPET radiotracersHuman subjectsReference regionReceptorsVT valuesKOR
2010
Synthesis and evaluation of [C-11]LY2795050, an antagonist PET imaging tracer for the kappa opioid receptors
Zheng M, Nabulsi N, Tomasi G, Mitch C, Quimby S, Barth V, Rash K, Masters J, Navarro A, Seest E, Carson R, Huang Y. Synthesis and evaluation of [C-11]LY2795050, an antagonist PET imaging tracer for the kappa opioid receptors. NeuroImage 2010, 52: s120. DOI: 10.1016/j.neuroimage.2010.04.098.Peer-Reviewed Original ResearchImaging the kappa opioid receptor in humans with [11C]LY2795050: Tracer evaluation and test–retest reproducibility study
Huang Y, Williams W, Tomasi G, Zheng M, Lin S, Ropchan J, Labaree D, Olsen J, Tabriz M, Planeta-Wilson B, Tauscher J, Ding Y, Carson R, Neumeister A. Imaging the kappa opioid receptor in humans with [11C]LY2795050: Tracer evaluation and test–retest reproducibility study. NeuroImage 2010, 52: s199. DOI: 10.1016/j.neuroimage.2010.04.161.Peer-Reviewed Original Research