2023
Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential age
2020
Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J
Bini J, Holden D, Fontaine K, Mulnix T, Lu Y, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Carson RE. Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J. EJNMMI Research 2020, 10: 83. PMID: 32666239, PMCID: PMC7359974, DOI: 10.1186/s13550-020-00670-w.Peer-Reviewed Original ResearchDose-limiting organUrinary bladderTime-activity curvesSynaptic densityOLINDA/EXM 1.0 softwareWhole-body PET scansWhole-body scanHuman adultsDose limitTotal radiation doseGastrointestinal tractPET scansHealthy adultsInjected activityRegion of interestLarge intestineNeuropsychiatric disordersEffective doseRelevant disordersBladderLiverRadiation doseAdultsMBqHigh uptake
2002
Brain Incorporation of [11C]Arachidonic Acid in Young Healthy Humans Measured With Positron Emission Tomography
Giovacchini G, Chang M, Channing M, Toczek M, Mason A, Bokde A, Connolly C, Vuong B, Ma Y, Der M, Doudet D, Herscovitch P, Eckelman W, Rapoport S, Carson R. Brain Incorporation of [11C]Arachidonic Acid in Young Healthy Humans Measured With Positron Emission Tomography. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1453-1462. DOI: 10.1097/00004647-200212000-00006.Peer-Reviewed Original ResearchPositron emission tomographyArachidonic acidBrain incorporationEmission tomographyHuman brainCerebral blood volumeYoung healthy humansYoung healthy adultsRole of AAVivo quantitative methodBrain radioactivityAwake ratsHealthy humansPharmacological activationBlood volumeRat studiesHealthy adultsWhite matterArterial input functionBrainPhospholipase A2Important second messengerSignal transductionTomographySecond messenger