2019
Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects
Guehl N, Wooten D, Yokell D, Moon S, Dhaynaut M, Katz S, Moody K, Gharagouzloo C, Kas A, Johnson K, El Fakhri G, Normandin M. Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects. European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46: 2099-2111. PMID: 31332496, PMCID: PMC6709592, DOI: 10.1007/s00259-019-04419-z.Peer-Reviewed Original ResearchConceptsReference tissue methodDistribution volume ratioTissue methodIn vivo quantificationPharmacokinetic modeling strategiesArterial plasma input functionMultilinear reference tissue methodsTwo-tissue compartment modelBlood:plasma ratioTissue-to-plasmaPlasma input functionPlasma concentration time courseBlood-based methodMethodsThirty-five subjectsSUV ratioBlood-based analysesData setsArterial input functionPET scansControl subjectsMild cognitive impairmentPlasma ratioRadiometabolite analysisHealthy controlsConcentration time course
2017
Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts
Albrecht D, Normandin M, Shcherbinin S, Wooten D, Schwarz A, Zürcher N, Barth V, Guehl N, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker J, Loggia M. Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts. Journal Of Nuclear Medicine 2017, 59: 107-114. PMID: 28818984, PMCID: PMC5750517, DOI: 10.2967/jnumed.116.178335.Peer-Reviewed Original ResearchConceptsChronic low back painPseudoreference regionGroup differencesDistribution volume ratioOccipital cortexArterial input functionChronic low back pain patientsAbsence of group differencesNo significant group differencesTranslocator protein imagingLow back painRegional group differencesSignificant group differencesAmyotrophic lateral sclerosisTranslocator proteinMatched healthy controlsDetect group differencesWithin-group variabilityBack painNeuroimmune activationVoxelwise analysisPET scansHealthy controlsClinical cohortDistribution volume