2022
Differences in the association between kappa opioid receptors and pain among Black and White adults with alcohol use disorders
de Laat B, Nabulsi N, Huang Y, O'Malley SS, Morris ED, Krishnan‐Sarin S. Differences in the association between kappa opioid receptors and pain among Black and White adults with alcohol use disorders. Alcohol Clinical And Experimental Research 2022, 46: 1348-1357. PMID: 35633151, DOI: 10.1111/acer.14879.Peer-Reviewed Original ResearchConceptsCold pressor testAlcohol use disorderKappa-opioid receptorsPositron emission tomographyOpioid receptorsNaltrexone effectsUse disordersWhite participantsOpioid antagonist naltrexoneBlack participantsKOR involvementNaltrexone treatmentPain recoveryAntagonist naltrexoneOpioid systemNaltrexoneAlcohol cravingPainWhite adultsUnderlying biological basisEmission tomographyWhite individualsMore alcoholTreatmentPreliminary findings
2019
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study
Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y. Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study. Neuropsychopharmacology 2019, 44: 1720-1727. PMID: 31026862, PMCID: PMC6785004, DOI: 10.1038/s41386-019-0398-4.Peer-Reviewed Original ResearchConceptsCocaine use disorderStress-induced relapsePositron emission tomographyCocaine bingeKappa-opioid receptor/dynorphin systemKOR selective agonistPositron emission tomography studyKappa-opioid receptorsCold pressor testCocaine self-administration sessionsEmission tomography studiesSelf-administration sessionsStress-induced cocaineEndogenous dynorphinDynorphin systemHealthy controlsPressor testSelective agonistPET scansAnimal studiesKOR bindingReceptor availabilitySignificant associationBrain regionsEmission tomography