Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis
Mercer J, Argus J, Crabtree D, Keenan M, Wilks M, Ashley J, Bensinger S, Lavau C, Wechsler D. Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis. PLOS ONE 2015, 10: e0129776. PMID: 26075887, PMCID: PMC4467867, DOI: 10.1371/journal.pone.0129776.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiosynthetic PathwaysCell LineCholesterolGene ExpressionGene Knockout TechniquesHomeostasisHumansMiceMonomeric Clathrin Assembly ProteinsOrgan SpecificityProtein TransportReceptors, LDLRNA InterferenceRNA, Small InterferingConceptsSingle nucleotide polymorphismsGenome-wide association studiesClathrin-mediated endocytosisCellular cholesterol homeostasisGene expression studiesExpression of genesPICALM expressionHeterologous proteinsEncode proteinsAssociation studiesPICALMNucleotide polymorphismsChromosomal translocationsExpressed proteinsCholesterol biosynthesisModulate macroautophagyCholesterol homeostasisBiological rolePathway analysisFlow cytometry analysisLDLR expressionLDL receptorLevels of LDLR expressionAlzheimer's diseasePool size