2024
Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV
Schnittman S, Talathi R, Wilks M, Hedgire S, Lu M, Fourman L, Alagpulinsa D, Stockman S, White K, Wallis Z, Autissier P, Stanley T, Lee H, Honigberg M, El-Fakhri G, Williams K, Zanni M, Grinspoon S, Toribio M. Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV. AIDS 2024, 38: 1940-1946. PMID: 38905489, DOI: 10.1097/qad.0000000000003967.Peer-Reviewed Original ResearchArterial infiltrationCardiovascular diseaseIncreased risk of cardiovascular diseaseHuman immunodeficiency virusT cell subtypesT lymphocyte subpopulationsRisk of cardiovascular diseaseSystemic monocyte activationCardiovascular disease riskImmunodeficiency virusMonocyte activationHIV statusIncreased riskRelevant to atherogenesisHIVInfiltrationGeneral populationPWHEvidence of interactionSubtypesDiseaseSubpopulationsAtherogenesis
2022
Increased Macrophage-Specific Arterial Infiltration Relates to Noncalcified Plaque and Systemic Immune Activation in People With Human Immunodeficiency Virus
Toribio M, Wilks M, Hedgire S, Lu M, Cetlin M, Wang M, Alhallak I, Durbin C, White K, Wallis Z, Schnittman S, Stanley T, El-Fakhri G, Lee H, Autissier P, Zanni M, Williams K, Grinspoon S. Increased Macrophage-Specific Arterial Infiltration Relates to Noncalcified Plaque and Systemic Immune Activation in People With Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2022, 226: 1823-1833. PMID: 35856671, PMCID: PMC10205602, DOI: 10.1093/infdis/jiac301.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAtherosclerotic cardiovascular diseaseAortic plaque volumeSystemic immune activationArterial infiltrationImmune activationImmunodeficiency virusPlaque volumeHistory of clinical ASCVDCD4+/CD8+ T-cell ratioHuman immunodeficiency virus statusCD8+ T cellsMarkers of immune activationClinical atherosclerotic cardiovascular diseasePersistent immune activationT cell ratioAtherosclerotic cardiovascular disease riskT cellsImmune phenotypeNoncalcified plaqueSystemic markersASCVD riskPWHCardiovascular diseaseUptake volume
2017
Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals
Zanni M, Toribio M, Wilks M, Lu M, Burdo T, Walker J, Autissier P, Foldyna B, Stone L, Martin A, Cope F, Abbruzzese B, Brady T, Hoffmann U, Williams K, El-Fakhri G, Grinspoon S. Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals. The Journal Of Infectious Diseases 2017, 215: 1264-1269. PMID: 28204544, PMCID: PMC5853590, DOI: 10.1093/infdis/jix095.Peer-Reviewed Original ResearchMeSH KeywordsAortaAtherosclerosisCase-Control StudiesCross-Sectional StudiesDextransHIV InfectionsHumansLectins, C-TypeLymph NodesMacrophagesMaleMannansMannose ReceptorMannose-Binding LectinsMiddle AgedPlaque, AtheroscleroticRadiopharmaceuticalsReceptors, Cell SurfaceRegression AnalysisSingle Photon Emission Computed Tomography Computed TomographyTechnetium Tc 99m PentetateUnited StatesConceptsSingle-photon emission computed tomography/computed tomographyFirst-in-human dataNon-HIV-infected subjectsAortic plaque volumeHIV-infected subjectsHIV-infected individualsMacrophages ex vivoComputed tomographic angiographyCD206+ macrophagesTomography/computed tomographyTomographic angiographyImaging techniquesTechnetium TcHIV statusPlaque volumeCardiovascular diseaseHIVImaging strategiesCD206In vivo applicationsSubjectsTilmanoceptAngiographyMacrophagesTomography