Further evaluation of [11C]MP‐10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis
Lin S, Labaree D, Chen M, Holden D, Gallezot J, Kapinos M, Teng J, Najafzadeh S, Plisson C, Rabiner EA, Gunn RN, Carson RE, Huang Y. Further evaluation of [11C]MP‐10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis. Synapse 2014, 69: 86-95. PMID: 25450608, PMCID: PMC4275380, DOI: 10.1002/syn.21792.Peer-Reviewed Original ResearchConceptsRhesus monkeysPhosphodiesterase 10ASprague-Dawley ratsMP-10Dose-dependent mannerSpecific PET tracersHigh specific bindingPET imaging studiesTissue uptake kineticsBaseline scanBrain regionsImaging studiesFurther evaluationMultilinear analysis methodRegional volumesPET tracersNonhuman primatesPET imagingVivo studiesReference tissueMonkeysBrainCerebellumSpecific bindingPresent studyUse of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta).
Caporizzo DJ, Kwiatkowski AE, Chen MK, Beck AP, Booth CJ, Zeiss C, Smith PC, Carlson Scholz JA, Wilson SR. Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta). Comparative Medicine 2014, 64: 211-20. PMID: 24956213, PMCID: PMC4067585.Peer-Reviewed Case Reports and Technical NotesConceptsIntestinal adenocarcinomaAdvanced ageFluorodeoxyglucose positron emission tomography-computed tomographyPositron emission tomography-computed tomographyPositron emission tomography-CTEmission tomography-computed tomographyRhesus macaquesAged female rhesus macaquesInconclusive radiographic findingsFocal FDG uptakeTomography-computed tomographyNoninvasive diagnostic toolFemale rhesus macaquesExploratory laparotomyFDG uptakeFDG-PETGastrointestinal adenocarcinomasRadiographic findingsTomography-CTClinical signsTransmural massAdenocarcinomaSmall intestineConventional radiographyNonhuman primates