Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons
Naganawa M, Lin SF, Lim K, Labaree D, Ropchan J, Harris P, Huang Y, Ichise M, Carson RE, Cline GW. Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons. Nuclear Medicine And Biology 2016, 43: 743-751. PMID: 27673755, PMCID: PMC5248981, DOI: 10.1016/j.nucmedbio.2016.08.018.Peer-Reviewed Original ResearchConceptsRenal cortexPositron emission tomographyInactive enantiomerRadiometabolite fractionΒ-cell massHuman β-cell massNon-displaceable bindingEx vivo studyF-FPLow inter-subject variabilityPET scansDTBZ bindingSpleen uptakeDistribution volumeEmission tomographySpleenPancreasDTBZCortexVivo studiesTissue samplesInter-subject variabilityHigh uptakePET signalRadiometabolitesComparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK‐6577 in baboons
Zheng MQ, Lin SF, Holden D, Naganawa M, Ropchan JR, Najafzaden S, Kapinos M, Tabriz M, Carson RE, Hamill TG, Huang Y. Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK‐6577 in baboons. Synapse 2016, 70: 112-120. PMID: 26671330, DOI: 10.1002/syn.21879.Peer-Reviewed Original ResearchAnimalsBenzamidesBrainBrain MappingCarbon RadioisotopesChromatography, High Pressure LiquidDrug Evaluation, PreclinicalFemaleGlycine AgentsGlycine Plasma Membrane Transport ProteinsKineticsLinear ModelsMagnetic Resonance ImagingMolecular StructurePapioPositron-Emission TomographyRadiopharmaceuticalsSulfonamides