2024
Synaptic density patterns in early Alzheimer’s disease assessed by independent component analysis
Fang X, Raval N, O’Dell R, Naganawa M, Mecca A, Chen M, van Dyck C, Carson R. Synaptic density patterns in early Alzheimer’s disease assessed by independent component analysis. Brain Communications 2024, 6: fcae107. PMID: 38601916, PMCID: PMC11004947, DOI: 10.1093/braincomms/fcae107.Peer-Reviewed Original ResearchMedial temporal brain regionsAlzheimer's diseaseTemporal brain regionsCognitive deficitsBrain regionsCognitive impairmentPostmortem studiesBinds to SV2ASynaptic densityReduction of synaptic densityIndependent component analysisSynaptic lossAlzheimerDeficitsImpairmentBrainNeocortexComponent analysisPrimary pathologySV2A
2007
Temporal and spatial blood information estimation using Bayesian ICA in dynamic cerebral positron emission tomography
Naganawa M, Kimura Y, Ishii K, Oda K, Ishiwata K. Temporal and spatial blood information estimation using Bayesian ICA in dynamic cerebral positron emission tomography. Digital Signal Processing 2007, 17: 979-993. DOI: 10.1016/j.dsp.2007.03.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVolume imagesHuman brain PET studiesEnsemble learningSource imagesInformation estimationStandard independent component analysisBlood informationIndependent component analysisBlood volume imagesNonnegative constraintsCost functionImagesBrain PET studiesPET imagesGaussian distributionComponent analysisLearningTomographic imagesSchemePriorsCerebral positron emission tomographyInformationConstraintsMethod
2005
Extraction of a plasma time-activity curve from dynamic brain PET images based on independent component analysis
Naganawa M, Kimura Y, Ishii K, Oda K, Ishiwata K, Matani A. Extraction of a plasma time-activity curve from dynamic brain PET images based on independent component analysis. IEEE Transactions On Biomedical Engineering 2005, 52: 201-210. PMID: 15709657, DOI: 10.1109/tbme.2004.840193.Peer-Reviewed Original ResearchConceptsBrain PET imagesIndependent component analysisVolume imagesDynamic PET imagesPET imagesDynamic positron emission tomography (PET) dataAppropriate preprocessingBlood volume imagesImagesComponent analysisObjective functionPositron emission tomography dataComputer simulationsBrain FDG-PET studiesTomography dataPlasma time-activity curvePreprocessingNew methodEmission tomography dataSerial arterial blood samplingModelInput functionExtraction