2020
Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET
Naganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET. EJNMMI Physics 2020, 7: 67. PMID: 33226522, PMCID: PMC7683759, DOI: 10.1186/s40658-020-00330-x.Peer-Reviewed Original ResearchPopulation-based input functionImage-derived input functionInitial distribution volumeArterial input functionInjected doseBlood samplingWhole bodyStandard arterial input functionInitial plasma concentrationsArterial blood samplingOncological patientsPlasma concentrationsGold standard methodDistribution volumePET studiesPET imagingSubject heightInput functionAUCAUC valuesTest-retest dataClinical environmentLater time windowKi valuesImaging
2019
Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers
Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y. Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers. Neuropsychopharmacology 2019, 44: 1714-1719. PMID: 30928993, PMCID: PMC6785144, DOI: 10.1038/s41386-019-0379-7.Peer-Reviewed Original ResearchConceptsBody mass indexKappa-opioid receptorsPositron emission tomographyAgonist radiotracerKOR systemOpioid receptorsTime-activity curvesBarratt Simplified MeasureAnterior cingulate cortexArterial blood samplingMultilinear analysis-1 (MA1) methodPET imaging studiesKOR levelsMass indexPreclinical modelsFrontal cortexHealthy volunteersRegional time-activity curvesBlood samplingPET scansCingulate cortexImaging studiesEmission tomographyVentral striatumRegional volumes
2014
Test-retest variability of adenosine A2A binding in the human brain with 11C-TMSX and PET
Naganawa M, Mishina M, Sakata M, Oda K, Hiura M, Ishii K, Ishiwata K. Test-retest variability of adenosine A2A binding in the human brain with 11C-TMSX and PET. EJNMMI Research 2014, 4: 76. PMID: 25621197, PMCID: PMC4293456, DOI: 10.1186/s13550-014-0076-9.Peer-Reviewed Original ResearchTest-retest variabilityCerebral cortexCentrum semiovaleMethodsFive healthy volunteersNon-displaceable uptakeLow test-retest variabilityReference regionArterial blood samplingTest-retest reproducibilityCandidate reference regionsHuman brainTest-retest studyHealthy volunteersAdenosine A2ABlood samplingDistribution volumeInvasive methodNoninvasive methodReceptor quantificationBPNDCortexBrainPresent studySimilar levelsPET
2005
Omission of serial arterial blood sampling in neuroreceptor imaging with independent component analysis
Naganawa M, Kimura Y, Nariai T, Ishii K, Oda K, Manabe Y, Chihara K, Ishiwata K. Omission of serial arterial blood sampling in neuroreceptor imaging with independent component analysis. NeuroImage 2005, 26: 885-890. PMID: 15955498, DOI: 10.1016/j.neuroimage.2005.02.025.Peer-Reviewed Original ResearchConceptsArterial blood samplingBlood samplingCerebral glucose metabolismAdenosine A1 receptorsTotal distribution volumeSerial arterial blood samplingLogan plotPET imagesPlasma time-activity curveA1 receptorsHealthy subjectsGlucose metabolismTime-activity curvesDistribution volumeBrain diseasesDVTReference regionSubjectsParametric imagesDynamic PET images