2011
Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET
Sullivan JM, Risacher SL, Normandin MD, Yoder KK, Froehlich JC, Morris ED. Imaging of alcohol‐induced dopamine release in rats:Preliminary findings with [11C]raclopride PET. Synapse 2011, 65: 929-937. PMID: 21308803, PMCID: PMC3130821, DOI: 10.1002/syn.20921.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBlood alcohol concentrationSmall animal positron emission tomographyRat striatumAnimal positron emission tomographyP ratsAlcohol-induced dopamine releaseSignificant alcohol-induced decreaseAlcohol-induced decreaseBlood alcohol levelsLateral saphenous veinAlcohol-preferring ratsAnimals 10 minSystemic alcoholDA releaseMicrodialysis studyStriatal dopamineAlcohol administrationSaphenous veinMale WistarDopamine releaseLarge cohortExtracellular dopamineBlood samplesReceptor availability
2005
ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release
Morris ED, Yoder KK, Wang C, Normandin MD, Zheng QH, Mock B, Raymond F, Froehlich JC. ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release. Molecular Imaging 2005, 4: 7290.2005.05130. PMID: 16285909, DOI: 10.2310/7290.2005.05130.Peer-Reviewed Original ResearchConceptsNeurotransmitter releaseArterial blood samplingEndogenous neurotransmitter releasePositron emission tomographyEndogenous dopamineDrug treatmentRat striatumBlood samplingBlood flowEmission tomographyFalse-positive responsesD3 receptor ligandsDopamine concentrationsPET imagingReceptor ligandsNoninvasive assayTracer kinetic modelReference regionStimulus conditionsDopamine