2024
Novel multi-modal methodology to investigate placebo response in major depressive disorder
Cusin C, Dillon D, Belleau E, Normandin M, Petibon Y, El-Fakri G, Dhaynaut M, Hooker J, Kaptchuk T, McKee M, Hayden E, Meyer A, Jahan A, Origlio J, Ang Y, Brunner D, Kang M, Long Y, Fava M, Pizzagalli D. Novel multi-modal methodology to investigate placebo response in major depressive disorder. Journal Of Affective Disorders 2024, 368: 1-7. PMID: 39233242, DOI: 10.1016/j.jad.2024.08.226.Peer-Reviewed Original ResearchPlacebo responseDepressive disorderRates of placebo responseMesocorticolimbic dopaminergic pathwayExpectation of rewardAntidepressant responseMesolimbic systemReward circuitryNeurobiological underpinningsNeurobiological mechanismsDopaminergic activityDopaminergic systemPlacebo respondersSymptom reductionDopaminergic pathwaysMulti-modal methodologyPlacebo phenomenonPsychological constructsTreatment developmentMDDPlacebo-controlledClinical trialsDouble-blindRewardDesigning clinical trialsAcute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors
Zhukovsky P, Ironside M, Duda J, Moser A, Null K, Dhaynaut M, Normandin M, Guehl N, El Fakhri G, Alexander M, Holsen L, Misra M, Narendran R, Hoye J, Morris E, Esfand S, Goldstein J, Pizzagalli D. Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors. Biological Psychiatry 2024, 96: 717-726. PMID: 38395372, PMCID: PMC11339240, DOI: 10.1016/j.biopsych.2024.02.005.Peer-Reviewed Original ResearchMajor depressive disorderFunctional connectivityEffects of stressAcute stressK-opioid receptorsStriatal connectivityEtiology of major depressive disorderCortical regionsMontreal Imaging Stress TaskEffects of acute stressGlobal FCIncreased striatal connectivityVentral attention/salience networkAllen Human Brain AtlasDefault mode networkCortical connectivityHuman Brain AtlasMDD studiesDepressive disorderFrontoparietal networkNeurobiological effectsMode networkStress taskDimensional approachMDD risk
2022
A multi-pronged investigation of option generation using depression, PET and modafinil
Ang Y, Cusin C, Petibon Y, Dillon D, Breiger M, Belleau E, Normandin M, Schroder H, Boyden S, Hayden E, Levine M, Jahan A, Meyer A, Kang M, Brunner D, Gelda S, Hooker J, Fakhri G, Fava M, Pizzagalli D. A multi-pronged investigation of option generation using depression, PET and modafinil. Brain 2022, 145: 1854-1865. PMID: 35150243, PMCID: PMC9166534, DOI: 10.1093/brain/awab429.Peer-Reviewed Original ResearchConceptsD2/D3 receptor availabilitySelf-generated optionsDepressive disorderDepressed individualsReceptor availabilityDopamine D2/D3 receptor availabilityNon-depressed adultsEffects of modafinilPutamen of patientsAssociated with uniquenessOption generationD2/D3 receptorsDopaminergic activityClinical depressionBinding potentialModafinilHealthy participantsPutamenPlacebo-controlledSamples of healthy peopleDouble-blindDisordersSelf-generationHealthy controlsDopamine
2021
Exploring Gender Differences in the Placebo Response to Major Depressive Disorder (MDD) Using Neuroimaging Techniques
Jahan A, Dillon D, Petibon Y, Meyer A, Normandin M, Belleau E, Alpert N, Fakhri G, Hooker J, Crowley D, Cusin C, Pizzagalli D, Fava M. Exploring Gender Differences in the Placebo Response to Major Depressive Disorder (MDD) Using Neuroimaging Techniques. Biological Psychiatry 2021, 89: s171-s172. DOI: 10.1016/j.biopsych.2021.02.438.Peer-Reviewed Original Research
2019
Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder
Pizzagalli D, Berretta S, Wooten D, Goer F, Pilobello K, Kumar P, Murray L, Beltzer M, Boyer-Boiteau A, Alpert N, Fakhri G, Mechawar N, Vitaliano G, Turecki G, Normandin M. Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder. JAMA Psychiatry 2019, 76: 854-861. PMID: 31042280, PMCID: PMC6495358, DOI: 10.1001/jamapsychiatry.2019.0801.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDA transporter availabilityVentral tegmental areaDA transporterDAT availabilityTegmental areaDepressive disorderDA signalingPositron emission tomographyDAT expressionMcLean HospitalHealthy controlsMajor depressive disorder groupsNumbers of depressive episodesStriatal dopamine transporter bindingDA transporter levelsLevels of DAT expressionStriatal DAT expressionStriatal DAT availabilityDA transporter densityDAT binding potentialDopamine transporter bindingOlder healthy controlsMesolimbic pathwayDA clearance