2024
The science and practice of imaging-based screening: What the radiologist needs to know
Milch H, Haramati L. The science and practice of imaging-based screening: What the radiologist needs to know. Clinical Imaging 2024, 114: 110266. PMID: 39216274, DOI: 10.1016/j.clinimag.2024.110266.Peer-Reviewed Original ResearchScreening practicesImaging-based screeningPublic health focusScreening guidelinesOpportunistic screeningHealth focusScreening examsScreening policyFormal trainingArtery diseaseEvidence developmentColorectal cancerLeadership opportunitiesBreast cancerClinician-scientistsAbdominal aortic aneurysmCoronary artery diseaseScreeningScreening conceptCarotid artery diseaseThyroid cancerCancerPracticeAortic aneurysmLung cancer
2018
Coronary Computed Tomography Angiography Versus Stress Echocardiography in Acute Chest Pain A Randomized Controlled Trial
Levsky J, Haramati L, Spevack D, Menegus M, Chen T, Mizrachi S, Brown-Manhertz D, Selesny S, Lerer R, White D, Tobin J, Taub C, Garcia M. Coronary Computed Tomography Angiography Versus Stress Echocardiography in Acute Chest Pain A Randomized Controlled Trial. JACC Cardiovascular Imaging 2018, 11: 1288-1297. PMID: 29909113, DOI: 10.1016/j.jcmg.2018.03.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAngina PectorisClinical Decision-MakingComparative Effectiveness ResearchComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseEchocardiography, StressEmergency Service, HospitalFemaleHumansLength of StayMaleMiddle AgedMultidetector Computed TomographyPatient AdmissionPatient SelectionPredictive Value of TestsRadiation DosageRadiation ExposureTreatment OutcomeTriageConceptsCoronary CTACardiovascular eventsHospital lengthAcute chest pain patientsMajor adverse cardiovascular eventsRadiation exposureMedian hospital lengthAdverse cardiovascular eventsMedian ED lengthChest pain patientsCoronary artery diseaseEmergency department useSerum troponin levelsChest pain triageCTA patientsPrimary endpointSafety endpointSecondary endpointsPatient ageTroponin levelsArtery diseaseED lengthPain patientsSE patientsStress echocardiography
2015
Coronary Computed Tomography Angiography Versus Radionuclide Myocardial Perfusion Imaging in Patients With Chest Pain Admitted to Telemetry: A Randomized Trial.
Levsky J, Spevack D, Travin M, Menegus M, Huang P, Clark E, Kim C, Hirschhorn E, Freeman K, Tobin J, Haramati L. Coronary Computed Tomography Angiography Versus Radionuclide Myocardial Perfusion Imaging in Patients With Chest Pain Admitted to Telemetry: A Randomized Trial. Annals Of Internal Medicine 2015, 163: 174-83. PMID: 26052677, PMCID: PMC4703121, DOI: 10.7326/m14-2948.Peer-Reviewed Original ResearchMeSH KeywordsCardiac CatheterizationChest PainComparative Effectiveness ResearchCoronary AngiographyCoronary Artery DiseaseFemaleFollow-Up StudiesHealth ResourcesHospital UnitsHumansLength of StayMaleMiddle AgedMyocardial Perfusion ImagingMyocardial RevascularizationPatient SatisfactionProspective StudiesRadiation DosageTelemetryTomography, X-Ray ComputedConceptsMyocardial perfusion imagingCCTA groupMPI groupCardiovascular eventsChest painCardiac catheterizationPrimary outcomeRadiation exposurePatient experienceStress myocardial perfusion imagingInner-city medical centerNonfatal cardiovascular eventsOutpatient cardiology visitsAcute chest painMajor cardiovascular eventsIntermediate-term outcomesEmergency department visitsCoronary artery diseaseComparative effectiveness trialIncidence of deathLength of stayAmerican Heart AssociationClinical management decisionsRadionuclide myocardial perfusionLess radiation exposure
2014
Myocardial Viability and Microvascular Obstruction
Romero J, Lupercio F, Haramati L, Garcia M, Lucariello R. Myocardial Viability and Microvascular Obstruction. Cardiology In Review 2014, 22: 246-252. PMID: 24621860, DOI: 10.1097/crd.0000000000000024.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseSystolic dysfunctionArtery diseaseMicrovascular obstructionMyocardial viabilityCardiac magnetic resonance imagingCardiac magnetic resonanceNew therapeutic strategiesMagnetic resonance imagingCardio-vascular medicinesPathophysiologic mechanismsStunned myocardiumTherapeutic strategiesMortality rateVascular medicineResonance imagingPotential pivotal roleAdult AmericansDysfunctionObstructionDiseasePivotal roleMagnetic resonanceMorbidityPatients
2013
Rationale and Design of a Randomized Trial Comparing Initial Stress Echocardiography versus Coronary CT Angiography in Low‐to‐Intermediate Risk Emergency Department Patients with Chest Pain
Levsky J, Haramati L, Taub C, Spevack D, Menegus M, Travin M, Vega S, Lerer R, Brown‐Manhertz D, Hirschhorn E, Tobin J, Garcia M. Rationale and Design of a Randomized Trial Comparing Initial Stress Echocardiography versus Coronary CT Angiography in Low‐to‐Intermediate Risk Emergency Department Patients with Chest Pain. Echocardiography 2013, 31: 744-750. PMID: 24372760, DOI: 10.1111/echo.12464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAged, 80 and overCausalityChest PainComorbidityCoronary AngiographyCoronary Artery DiseaseEchocardiographyEmergency Service, HospitalExercise TestFemaleHealth Care CostsHospitalizationHumansIncidenceMaleMiddle AgedNew YorkResearch DesignRisk AssessmentTomography, X-Ray ComputedYoung AdultConceptsTreadmill stress echocardiographyStress echocardiographyEmergency departmentComparative effectiveness researchChest painED chest pain patientsMajor adverse cardiovascular eventsRisk Emergency Department PatientsSignificant coronary artery diseaseED/hospitalAcute chest painAdverse cardiovascular eventsIncidence of hospitalizationChest pain patientsCoronary artery diseaseEmergency department patientsImaging modalitiesLength of stayCoronary CT angiographyDecrease healthcare expendituresNoninvasive diagnostic algorithmCost of careNoninvasive imaging modalityCardiovascular eventsObservational registryResting cardiac 64-MDCT does not reliably detect myocardial ischemia identified by radionuclide imaging.
Spiro A, Haramati L, Jain V, Godelman A, Travin M, Levsky J. Resting cardiac 64-MDCT does not reliably detect myocardial ischemia identified by radionuclide imaging. American Journal Of Roentgenology 2013, 200: 337-42. PMID: 23345355, DOI: 10.2214/ajr.11.8171.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCardiac-Gated Imaging TechniquesContrast MediaCoronary AngiographyFemaleHumansMaleMiddle AgedMyocardial IschemiaPositron-Emission TomographyPredictive Value of TestsRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesSensitivity and SpecificityStatistics, NonparametricTomography, X-Ray ComputedTriiodobenzoic AcidsConceptsMyocardial perfusion imagingNegative predictive valuePositive predictive valuePredictive valueSubendocardial perfusionMyocardial ischemiaMyocardial segmentsPerfusion imagingObstructive coronary artery diseaseRadionuclide myocardial perfusion imagingCoronary artery diseaseCT myocardial perfusion imagingSignificant differencesAmerican Heart Association segmentsArtery diseaseDiastolic perfusionNonischemic segmentsCT perfusionDiagnostic modalitiesCT angiographyMyocardial perfusionClinical practiceIschemiaPerfusionClinical use
2011
ACR Appropriateness Criteria® Chronic Chest Pain—High Probability of Coronary Artery Disease
Earls J, White R, Woodard P, Abbara S, Atalay M, Carr J, Haramati L, Hendel R, Ho V, Hoffman U, Khan A, Mammen L, Martin E, Rozenshtein A, Ryan T, Schoepf J, Steiner R, White C. ACR Appropriateness Criteria® Chronic Chest Pain—High Probability of Coronary Artery Disease. Journal Of The American College Of Radiology 2011, 8: 679-686. PMID: 21962781, DOI: 10.1016/j.jacr.2011.06.022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsChest PainChronic DiseaseCoronary Artery DiseaseDiagnosis, DifferentialDiagnostic ImagingEchocardiography, StressEvidence-Based MedicineFemaleHumansMagnetic Resonance AngiographyMalePositron-Emission TomographyPractice Guidelines as TopicRadiation ProtectionReproducibility of ResultsRisk AssessmentSocieties, MedicalTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsACR Appropriateness CriteriaCoronary artery diseaseArtery diseaseAppropriateness CriteriaMyocardial ischemiaChronic chest painMultidetector cardiac CTAppropriateness of imagingObstructive coronary lesionsSingle-photon emission CTLong-term prognosisIschemic heart diseaseMultidisciplinary expert panelEvidence-based guidelinesConventional coronary angiographyChronic myocardial ischemiaSpecific clinical conditionsCurrent medical literaturePhoton emission CTChest painPeer-reviewed journalsAngina pectorisCoronary angiographyMedical therapyCoronary lesions
2009
Efficacy of coronary CT angiography: Where we are, where we are going, and where we want to be
Levsky J, Kim C, Spevack D, Travin M, Tobin J, Haramati L. Efficacy of coronary CT angiography: Where we are, where we are going, and where we want to be. Journal Of Cardiovascular Computed Tomography 2009, 3: s99-s108. PMID: 20129523, DOI: 10.1016/j.jcct.2009.10.008.Commentaries, Editorials and LettersConceptsCoronary CT angiographyCT angiographyRadionuclide myocardial perfusion imagingCardiovascular event ratesCoronary artery diseaseMyocardial perfusion imagingClinical decision makingComparative effectiveness researchPotential study designsArtery diseaseEarly triageConsensus statementImaging examinationsNoninvasive examinationPerfusion imagingAngiographyEvent ratesAssessment of levelsStudy designEarly introductionPotential roleEffectiveness researchEfficacyPivotal publicationsExaminationACR Appropriateness Criteria® on Acute Respiratory Illness
Washington L, Khan A, Mohammed T, Batra P, Gurney J, Haramati L, Jeudy J, MacMahon H, Rozenshtein A, Vydareny K, Kaiser L, Raoof S. ACR Appropriateness Criteria® on Acute Respiratory Illness. Journal Of The American College Of Radiology 2009, 6: 675-680. PMID: 19800586, PMCID: PMC7106070, DOI: 10.1016/j.jacr.2009.06.022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute respiratory illnessRespiratory illnessRisk factorsPositive physical examinationAcute respiratory failureFebrile neutropenic patientsChest radiographic findingsACR Appropriateness CriteriaCongestive heart failureCoronary artery diseaseSeverity of illnessDifferent clinical settingsRespiratory failureNeutropenic patientsArtery diseaseHeart failureSevere pneumoniaRadiographic findingsPhysical examinationRadiologic studiesChest CTClinical historyLaboratory findingsAppropriateness CriteriaChest imagingRationale and design of a randomized controlled trial comparing stress myocardial perfusion imaging with coronary CT angiography as the initial imaging study for intermediate-risk patients admitted with chest pain
Levsky J, Travin M, Spevack D, Menegus M, Huang P, Goldberg Y, Clark E, Banoth P, Freeman K, Tobin J, Haramati L. Rationale and design of a randomized controlled trial comparing stress myocardial perfusion imaging with coronary CT angiography as the initial imaging study for intermediate-risk patients admitted with chest pain. Journal Of Cardiovascular Computed Tomography 2009, 3: 264-271. PMID: 19577217, DOI: 10.1016/j.jcct.2009.05.006.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingIntermediate-risk patientsChest painMajor adverse cardiovascular eventsRadionuclide myocardial perfusion imagingIntermediate-risk characteristicsSubsequent coronary revascularizationAdverse cardiovascular eventsEvaluation of patientsStress myocardial perfusionAcute myocardial infarctionClinical outcome endpointsInitial imaging studyNoninvasive cardiac imagingCoronary CT angiographyEvidence-based medicineTerms of outcomesCardiovascular eventsCoronary revascularizationHospital stayRenal dysfunctionSubsequent hospitalizationSecondary outcomesArtery disease
2008
CT angiography for evaluation of coronary artery disease in inner-city outpatients: an initial prospective comparison with stress myocardial perfusion imaging
Haramati L, Levsky J, Jain V, Altman E, Spindola-Franco H, Bobra S, Doddamani S, Travin M. CT angiography for evaluation of coronary artery disease in inner-city outpatients: an initial prospective comparison with stress myocardial perfusion imaging. The International Journal Of Cardiovascular Imaging 2008, 25: 303-313. PMID: 18979224, DOI: 10.1007/s10554-008-9382-5.Peer-Reviewed Original ResearchMeSH KeywordsContrast MediaCoronary AngiographyCoronary Artery DiseaseFemaleHumansLogistic ModelsMaleMiddle AgedOutpatientsPredictive Value of TestsProspective StudiesRadiographic Image Interpretation, Computer-AssistedRadiopharmaceuticalsSensitivity and SpecificityStatistics, NonparametricTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedUrban PopulationConceptsCT coronary angiographyCoronary artery diseaseNegative predictive valuePositive predictive valueInner-city outpatientsPredictive valueArtery diseaseCoronary angiographyMyocardial perfusionStress SPECT myocardial perfusionHigh negative predictive valueSubsequent cardiac catheterizationStress myocardial perfusionEvaluation of CADSPECT myocardial perfusionHIPAA-compliant studyPositive SPECTCardiac catheterizationClinical endpointsOutpatient populationPatient outcomesPerfusion defectsProspective comparisonCT angiographyMore homogenous groupsEthical Trials to Determine the Risks and Benefits of Radiation Exposure from Coronary CT Angiography
Haramati L. Ethical Trials to Determine the Risks and Benefits of Radiation Exposure from Coronary CT Angiography. Journal Of The American College Of Radiology 2008, 5: 1073-1076. PMID: 18812151, DOI: 10.1016/j.jacr.2008.05.004.Commentaries, Editorials and LettersConceptsCoronary artery diseaseCoronary CT angiographyArtery diseaseCT angiographyFuture patientsRadiation exposureManagement of patientsDiagnostic radiation exposureRadiation-related cancerCommon causeAmerican CollegeDiagnostic radiationClinical researchPatientsAngiographyMedical researchRiskGenetic damageDiseaseHeritable genetic damageExposureEthical trialsCancerTrialsBenefits