2008
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.Peer-Reviewed Original ResearchConceptsSmaller hippocampus volumesHippocampus volumeBipolar disorderBDNF genotypeBD diagnosisMood disorder pathophysiologyBDNF Val66Met polymorphismHigh-resolution magnetic resonanceHealthy comparison subjectsVal/Val homozygotesEffect of diagnosisLinear mixed model analysisVal66Met polymorphismGrowth factor proteinBD subgroupsDisorder pathophysiologyHC subjectsHippocampal developmentComparison subjectsMixed model analysisHippocampus structureBDNFHippocampus morphologyAnterior hippocampusVal homozygotes
2004
Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, Staib LH, Charney DS, Bremner JD. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry 2004, 56: 101-112. PMID: 15231442, DOI: 10.1016/j.biopsych.2004.04.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderUrinary free cortisolHippocampal volumeHealthy subjectsMemory deficitsDepressed patientsDepressive disorderCortisol statusSelective serotonin reuptake inhibitor (SSRI) treatmentSerotonin reuptake inhibitor treatmentWechsler Memory Scale-RevisedNormal hippocampal volumesReuptake inhibitor treatmentWhole hippocampal volumeWhole brain volumeDeclarative memory deficitsEffect of treatmentMemory functionDeclarative memory functionUFC excretionAntidepressant treatmentFree cortisolHippocampal dysfunctionBaseline plasmaSuccessful treatment
2003
MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, Khan S, Vaccarino LV, Soufer R, Garg PK, Ng CK, Staib LH, Duncan JS, Charney DS. MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder. American Journal Of Psychiatry 2003, 160: 924-932. PMID: 12727697, DOI: 10.1176/appi.ajp.160.5.924.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderChildhood sexual abuseHippocampal volumeEarly childhood sexual abuseHippocampal structureHippocampal functionAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesPositron emission tomographySexual abuseVerbal declarative memory tasksAnimal studiesBrain areasDeclarative memory taskEmission tomographyPET studiesHippocampal activationWomenEarly stressHippocampusAbused womenDisordersAbuseMagnetic resonanceNeural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib LH, Soufer R, Charney DS. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biological Psychiatry 2003, 53: 879-889. PMID: 12742675, DOI: 10.1016/s0006-3223(02)01891-7.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAbuse-related posttraumatic stress disorderMedial prefrontal cortexBrain areasPrefrontal cortexEarly childhood sexual abuseBlood flowChildhood abuse-related posttraumatic stress disorderSexual abuse-related posttraumatic stress disorderStress disorderChildhood sexual abuseCerebral blood flowPositron emission tomographic measurementsSpecific brain areasInferior temporal gyrusInferior parietal cortexMiddle frontal gyrusNeural correlatesTrauma-specific stimuliDeclarative memoryMotor cortexControl subjectsFrontal cortexSymptom provocationAnimal studies
2002
Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression
Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD. Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression. American Journal Of Psychiatry 2002, 159: 2072-2080. PMID: 12450959, PMCID: PMC3230324, DOI: 10.1176/appi.ajp.159.12.2072.Peer-Reviewed Original ResearchConceptsSmaller hippocampal volumesMajor depressive disorderHippocampal volumeDepressive disorderDepressed subjectsDepressed womenHealthy subjectsChildhood abuseUnipolar major depressive disorderRight hippocampal volumeCoronal MRI scansAdrenal axisDepressed patientsMajor depressionControl brain regionsTemporal lobeWhole hippocampusComparison subjectsMRI scansTrauma AssociatedEarly childhood traumaFemale volunteersWhole brainBrain regionsStudy participants
2000
Temporal lobe volume in panic disorder — a quantitative magnetic resonance imaging study
Vythilingam M, Anderson E, Goddard A, Woods S, Staib L, Charney D, Bremner J. Temporal lobe volume in panic disorder — a quantitative magnetic resonance imaging study. Psychiatry Research 2000, 99: 75-82. PMID: 10963983, DOI: 10.1016/s0925-4927(00)00055-x.Peer-Reviewed Original ResearchConceptsTemporal lobe volumePanic disorderTemporal lobeMagnetic resonance imagingControl subjectsHealthy subjectsLobe volumeSmaller temporal lobe volumeNormal hippocampal volumesMagnetic resonance imaging studyHealthy control subjectsRight temporal lobeQuantitative magnetic resonance imaging studyQuantitative MRI measuresWhole brain volumeResonance imaging studyHippocampal volumeBrain changesMRI measuresBrain volumeWhole brainPatientsQualitative abnormalitiesResonance imagingImaging studiesDecreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder
Bremner J, Innis R, Southwick S, Staib L, Zoghbi S, Charney D. Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder. American Journal Of Psychiatry 2000, 157: 1120-1126. PMID: 10873921, DOI: 10.1176/appi.ajp.157.7.1120.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingPosttraumatic stress disorderBenzodiazepine receptorsReceptor bindingPrefrontal cortexComparison subjectsCase-matched healthy comparison subjectsDistribution volumeStress disorderSymptoms of PTSDBenzodiazepine receptor functionLow distribution volumeHealthy comparison subjectsCombat-related posttraumatic stress disorderMedial prefrontal cortexCentral benzodiazepine receptorsSingle photon emissionStatistical parametric mappingFrontal cortexPTSD patientsPatientsReceptor functionCortexTomography imagingParametric mappingSPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder
Bremner J, Innis R, White T, Fujita M, Silbersweig D, Goddard A, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney D. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry 2000, 47: 96-106. PMID: 10664825, DOI: 10.1016/s0006-3223(99)00188-2.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingBenzodiazepine receptor functionPanic disorder patientsBenzodiazepine receptorsPanic disorderReceptor bindingDisorder patientsPanic attacksReceptor functionPrefrontal cortexSingle photon emissionStatistical parametric mappingGABAergic transmissionHealthy controlsFrontal cortexLeft hippocampusAnimal modelsComparison subjectsPatientsChronic stressPanic anxietyTomography imagingParametric mappingCortexSpecific decreaseHippocampal Volume Reduction in Major Depression
Bremner J, Narayan M, Anderson E, Staib L, Miller H, Charney D. Hippocampal Volume Reduction in Major Depression. American Journal Of Psychiatry 2000, 157: 115-118. PMID: 10618023, DOI: 10.1176/ajp.157.1.115.Peer-Reviewed Original ResearchConceptsSmaller left hippocampal volumeLeft hippocampal volumeHippocampal volumeMajor depressionComparison subjectsHippocampal volume reductionWhole brain volumeMagnetic resonance imagingNondepressed comparison subjectsAlcohol exposureBrain areasBrain volumeResonance imagingPatientsElevated levelsDepressionHippocampusVolume reductionComparison regionBrain sizeSubjectsRemissionGlucocorticoidsFindings
1997
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region