2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
2022
Machine Learning Models for Prediction of Posttreatment Recurrence in Early-Stage Hepatocellular Carcinoma Using Pretreatment Clinical and MRI Features: A Proof-of-Concept Study.
Iseke S, Zeevi T, Kucukkaya AS, Raju R, Gross M, Haider SP, Petukhova-Greenstein A, Kuhn TN, Lin M, Nowak M, Cooper K, Thomas E, Weber MA, Madoff DC, Staib L, Batra R, Chapiro J. Machine Learning Models for Prediction of Posttreatment Recurrence in Early-Stage Hepatocellular Carcinoma Using Pretreatment Clinical and MRI Features: A Proof-of-Concept Study. American Journal Of Roentgenology 2022, 220: 245-255. PMID: 35975886, PMCID: PMC10015590, DOI: 10.2214/ajr.22.28077.Peer-Reviewed Original ResearchConceptsEarly-stage hepatocellular carcinomaLiver transplantHepatocellular carcinomaImaging featuresPosttreatment recurrenceOrgan allocationMean AUCLiver transplant eligibilityPretreatment clinical characteristicsPretreatment MRI examinationsKaplan-Meier analysisKaplan-Meier curvesClinical characteristicsImaging surveillanceTherapy allocationTransplant eligibilityUnderwent treatmentClinical parametersRetrospective studyUnpredictable complicationMRI dataConcept studyPoor survivalClinical impactPretreatment MRI
2019
Scoring of Coronary Artery Disease Characteristics on Coronary CT Angiograms by Using Machine Learning
Johnson KM, Johnson HE, Zhao Y, Dowe DA, Staib LH. Scoring of Coronary Artery Disease Characteristics on Coronary CT Angiograms by Using Machine Learning. Radiology 2019, 292: 182061. PMID: 31237495, DOI: 10.1148/radiol.2019182061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleHumansImage Interpretation, Computer-AssistedMachine LearningMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRisk FactorsSeverity of Illness IndexYoung AdultConceptsCoronary CT angiographyCoronary Artery Disease ReportingNonfatal myocardial infarctionHeart disease deathCT angiographyCause mortalityDisease deathsMyocardial infarctionCoronary heart disease deathDisease reportingCoronary artery diseaseNational Death IndexData System scoreCardiovascular eventsCoronary deathAdverse eventsArtery diseaseCoronary diseaseDeath IndexCoronary segmentsPrognostic informationVessel scorePatientsSystem scoreSubsequent death
2018
Does MR enterography offer added value after a recent CT in the evaluation of abdominal pain in Crohn's disease patients?
Spektor M, Mathur M, Santacana G, Asch D, Huber S, Staib L, Israel G. Does MR enterography offer added value after a recent CT in the evaluation of abdominal pain in Crohn's disease patients? Clinical Imaging 2018, 54: 78-83. PMID: 30562678, DOI: 10.1016/j.clinimag.2018.12.002.Peer-Reviewed Original ResearchConceptsAbdominal painCrohn's diseaseDisease patientsHigher health care costsAcute abdominal painBowel wall thickeningCrohn's disease patientsContrast-enhanced CTStrict inclusion criteriaHealth care costsModerate interobserver agreementRecent CTBowel obstructionConsecutive patientsMR enterographyPatient riskInclusion criteriaBlinded reviewAbdominal radiologistsMRE examinationsCare costsWall thickeningFree fluidRoutine useDiagnostic CTBenefit of a Visual Aid in the Management of Moderate-Severity Contrast Media Reactions.
Gardner JB, Rashid S, Staib L, Asch D, Cavallo J, Arango J, Kirsch J, Pahade J. Benefit of a Visual Aid in the Management of Moderate-Severity Contrast Media Reactions. American Journal Of Roentgenology 2018, 211: 717-723. PMID: 30106614, DOI: 10.2214/ajr.18.19689.Peer-Reviewed Original ResearchAspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size
Johnson MB, Sun X, Kodani A, Borges-Monroy R, Girskis KM, Ryu SC, Wang PP, Patel K, Gonzalez DM, Woo YM, Yan Z, Liang B, Smith RS, Chatterjee M, Coman D, Papademetris X, Staib LH, Hyder F, Mandeville JB, Grant PE, Im K, Kwak H, Engelhardt JF, Walsh CA, Bae BI. Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature 2018, 556: 370-375. PMID: 29643508, PMCID: PMC6095461, DOI: 10.1038/s41586-018-0035-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological EvolutionCalmodulin-Binding ProteinsCentrosomeCerebral CortexDisease Models, AnimalFemaleFerretsGene DeletionGene EditingGene Expression Regulation, DevelopmentalGene Knockout TechniquesGerm-Line MutationHumansMaleMiceMicrocephalyNerve Tissue ProteinsNeural Stem CellsOrgan SizeTranscription, GeneticConceptsVentricular radial glial cellsEvolutionary mechanismsRadial glial cellsOuter radial gliaHuman primary microcephalyProtein sequence homologyAbnormal spindle-like microcephalyCerebral cortical sizeGlial cellsCortical sizeUndifferentiated cell typesNeural progenitor cellsRadial gliaASPM proteinCerebral cortical expansionMicrocephaly genesDivergent functionsGenome editingSequence homologyDifferentiated progenitorsOuter subventricular zoneCortical expansionPrimary microcephalyCell typesGermline knockout
2017
Disparities in Care Among Patients With Cardiac Implantable Electronic Devices Undergoing MRI
Cavallo JJ, Zhang Y, Staib LH, Lampert R, Weinreb JC. Disparities in Care Among Patients With Cardiac Implantable Electronic Devices Undergoing MRI. Journal Of The American College Of Radiology 2017, 14: 1566-1571. PMID: 28899705, DOI: 10.1016/j.jacr.2017.07.014.Peer-Reviewed Original ResearchAssessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction
Jindal G, Graeber BL, Staib LH, Silva CT. Assessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction. Pediatric Radiology 2017, 47: 1594-1598. PMID: 28681232, DOI: 10.1007/s00247-017-3920-z.Peer-Reviewed Original ResearchJOURNAL CLUB: Benefit of Epinephrine Autoinjector for Treatment of Contrast Reactions: Comparison of Errors, Administration Times, and Provider Preferences.
Asch D, Pfeifer KE, Arango J, Staib L, Cavallo J, Kirsch JD, Arici M, Pahade J. JOURNAL CLUB: Benefit of Epinephrine Autoinjector for Treatment of Contrast Reactions: Comparison of Errors, Administration Times, and Provider Preferences. American Journal Of Roentgenology 2017, 209: w363-w369. PMID: 28570127, DOI: 10.2214/ajr.16.17111.Peer-Reviewed Original Research
2016
Knowledge of Density and Screening Ultrasound
Moothathu NS, Philpotts LE, Busch SH, Gross CP, Staib LH, Hooley RJ. Knowledge of Density and Screening Ultrasound. The Breast Journal 2016, 23: 323-332. PMID: 27943500, DOI: 10.1111/tbj.12734.Peer-Reviewed Original ResearchConceptsBreast density awarenessBreast densityDense breast tissueScreening ultrasoundBreast cancerCaucasian raceBreast tissueBreast ultrasoundSupplemental breast ultrasoundBreast cancer riskBreast density notification lawsNon-Caucasian patientsPercent of participantsPhysician recommendationProvider recommendationAcademic breastSelf-administered surveyUltrasoundWomenPatientsCancerMammography reportsTissueAnxietyHigher incomeBrain responses to biological motion predict treatment outcome in young children with autism
Yang D, Pelphrey KA, Sukhodolsky DG, Crowley MJ, Dayan E, Dvornek NC, Venkataraman A, Duncan J, Staib L, Ventola P. Brain responses to biological motion predict treatment outcome in young children with autism. Translational Psychiatry 2016, 6: e948-e948. PMID: 27845779, PMCID: PMC5314125, DOI: 10.1038/tp.2016.213.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderYoung childrenSocial information processingMultivariate pattern analysisMotivation/rewardBiological motionCore deficitComplex neurodevelopmental disorderBrain responsesResponse treatmentSpectrum disorderNeurobiological markersNeural predictorsInformation processingBehavioral interventionsIndividual childrenNeurodevelopmental disordersCurrent findingsNeural circuitsBehavioral deficitsEarly childhoodChildrenUnsuccessful interventionsNeurobiomarkersPattern analysisPivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder
Venkataraman A, Yang D, Dvornek N, Staib LH, Duncan JS, Pelphrey KA, Ventola P. Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder. Neuroreport 2016, 27: 1081-1085. PMID: 27532879, PMCID: PMC5007196, DOI: 10.1097/wnr.0000000000000662.Peer-Reviewed Original ResearchConceptsPivotal Response TreatmentAutism spectrum disorderOccipital-temporal cortexAttentional systemResponse treatmentSpectrum disorderOrbitofrontal cortexPosterior cingulateHigh-level objectsBehavioral interventionsLearning mechanismPerception shiftProcessing areasNeural circuitsFunctional rewiringCortexTreatment regimenAutismInterventionNovel Bayesian frameworkCingulateFunctional changesIndividualsDisordersObjectsMagnetic Resonance Imaging and Sonography in the Diagnosis of Placental Invasion
Balcacer P, Pahade J, Spektor M, Staib L, Copel JA, McCarthy S. Magnetic Resonance Imaging and Sonography in the Diagnosis of Placental Invasion. Journal Of Ultrasound In Medicine 2016, 35: 1445-1456. PMID: 27229131, DOI: 10.7863/ultra.15.07040.Peer-Reviewed Original ResearchIs there an added value of a hepatobiliary phase with gadoxetate disodium following conventional MRI with an extracellular gadolinium agent in a single imaging session for detection of primary hepatic malignancies?
Pahade JK, Juice D, Staib L, Israel G, Cornfeld D, Mitchell K, Weinreb J. Is there an added value of a hepatobiliary phase with gadoxetate disodium following conventional MRI with an extracellular gadolinium agent in a single imaging session for detection of primary hepatic malignancies? Abdominal Radiology 2016, 41: 1270-1284. PMID: 26800701, DOI: 10.1007/s00261-016-0635-9.Peer-Reviewed Original Research
2015
High-Fidelity Contrast Reaction Simulation Training: Performance Comparison of Faculty, Fellows, and Residents
Pfeifer K, Staib L, Arango J, Kirsch J, Arici M, Kappus L, Pahade J. High-Fidelity Contrast Reaction Simulation Training: Performance Comparison of Faculty, Fellows, and Residents. Journal Of The American College Of Radiology 2015, 13: 81-87. PMID: 26549266, DOI: 10.1016/j.jacr.2015.08.016.Peer-Reviewed Original ResearchAnterior Cortical Development During Adolescence in Bipolar Disorder
Najt P, Wang F, Spencer L, Johnston JA, Lippard E, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP. Anterior Cortical Development During Adolescence in Bipolar Disorder. Biological Psychiatry 2015, 79: 303-310. PMID: 26033826, PMCID: PMC4595154, DOI: 10.1016/j.biopsych.2015.03.026.Peer-Reviewed Original ResearchConceptsWhite matter expansionBipolar disorderWhite matterAnterior cortexHealthy adolescentsHigh-resolution magnetic resonance imaging (MRI) scansMagnetic resonance imaging (MRI) scansWhite matter increasesResonance imaging scansGray matter decreasesDorsolateral prefrontal cortexMatter expansionHealthy groupImaging scansCortical volumeFrontal cortexNeurodevelopmental abnormalitiesCortical developmentAnterior paralimbicNeurodevelopmental modelLongitudinal neuroimagingPrefrontal cortexCortexLongitudinal studyAdolescentsThe clinical impact of gynecologic MRI.
Ratner ES, Staib LH, Cross SN, Raji R, Schwartz PE, McCarthy SM. The clinical impact of gynecologic MRI. American Journal Of Roentgenology 2015, 204: 674-80. PMID: 25714302, DOI: 10.2214/ajr.14.12567.Peer-Reviewed Original ResearchConceptsPelvic MRIFirst modalityClinical managementClinical impactGynecologic massesIndeterminate pelvic massesGroup of patientsResults of MRIRadiologic recordsRadiologic findingsPelvic massClinical recordsUnnecessary surgeryMedical recordsCT examinationsFurther endpointsExact diagnosisPatientsSurgeryIndeterminate massesPatient treatmentMRIDiagnosisModalitiesResultant anxietyUtility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions
Macer ML, Mathur M, Spektor M, Gysler S, Staib L, Kodaman P, McCarthy S. Utility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions. Journal Of Computer Assisted Tomography 2015, 39: 896-900. PMID: 26466105, DOI: 10.1097/rct.0000000000000302.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPelvic adhesionsPositive predictive valuePredictive valueResonance imagingSpecificity of MRIGynecologic abdominal surgeryInstitutional review board-approved retrospective analysisNegative predictive valueAnterior culPosterior culAbdominal surgeryOperative reportsInclusion criteriaRetrospective analysisStudy populationBlinded specialistsMRI sensitivityPatientsImaging
2014
Using SUV as a Guide to 18F-FDG Dose Reduction
Cheng DW, Ersahin D, Staib LH, Della Latta D, Giorgetti A, d’Errico F. Using SUV as a Guide to 18F-FDG Dose Reduction. Journal Of Nuclear Medicine 2014, 55: 1998-2002. PMID: 25453048, DOI: 10.2967/jnumed.114.140129.Peer-Reviewed Original ResearchDiffusion Tensor Imaging as a Predictor of Locomotor Function after Experimental Spinal Cord Injury and Recovery
Kelley BJ, Harel NY, Kim CY, Papademetris X, Coman D, Wang X, Hasan O, Kaufman A, Globinsky R, Staib LH, Cafferty WB, Hyder F, Strittmatter SM. Diffusion Tensor Imaging as a Predictor of Locomotor Function after Experimental Spinal Cord Injury and Recovery. Journal Of Neurotrauma 2014, 31: 1362-1373. PMID: 24779685, PMCID: PMC4120934, DOI: 10.1089/neu.2013.3238.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDiffusion tensor imagingCord injuryAxonal integrityLocomotor functionExperimental spinal cord injuryTraumatic spinal cord injuryFemale Sprague-Dawley ratsTensor imagingFractional anisotropyFunctional recovery assessmentSpinal cord contusionLimited functional recoveryLong-term disabilityQuantitative diffusion tensor imagingRodent SCI modelsSprague-Dawley ratsSpinal cord morphologyWhite matter pathologyCaudal spinal cordWhite matter integrityInjury epicenterMidthoracic laminectomyCord contusionPrimary outcome