2020
Regional myocardial strain analysis via 2D speckle tracking echocardiography: validation with sonomicrometry and correlation with regional blood flow in the presence of graded coronary stenoses and dobutamine stress
Stendahl JC, Parajuli N, Lu A, Boutagy NE, Guerrera N, Alkhalil I, Lin BA, Staib LH, O’Donnell M, Duncan JS, Sinusas AJ. Regional myocardial strain analysis via 2D speckle tracking echocardiography: validation with sonomicrometry and correlation with regional blood flow in the presence of graded coronary stenoses and dobutamine stress. Cardiovascular Ultrasound 2020, 18: 2. PMID: 31941514, PMCID: PMC6964036, DOI: 10.1186/s12947-019-0183-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationCoronary StenosisCoronary VesselsDisease Models, AnimalDogsEchocardiography, StressMyocardial ContractionRegional Blood FlowSystoleConceptsSpeckle tracking echocardiographyLow-dose dobutamine stressPost-systolic indexDobutamine stressCoronary stenosisBlood flow measurementsTracking echocardiographyAnesthetized open-chest dogsCircumferential strainLow-dose dobutamineMid-left anteriorModerate coronary stenosisOpen-chest dogsRegional blood flowAcute canine modelMyocardial strain analysisMicrosphere blood flow measurementsLAD stenosis
2018
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size
Johnson MB, Sun X, Kodani A, Borges-Monroy R, Girskis KM, Ryu SC, Wang PP, Patel K, Gonzalez DM, Woo YM, Yan Z, Liang B, Smith RS, Chatterjee M, Coman D, Papademetris X, Staib LH, Hyder F, Mandeville JB, Grant PE, Im K, Kwak H, Engelhardt JF, Walsh CA, Bae BI. Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature 2018, 556: 370-375. PMID: 29643508, PMCID: PMC6095461, DOI: 10.1038/s41586-018-0035-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological EvolutionCalmodulin-Binding ProteinsCentrosomeCerebral CortexDisease Models, AnimalFemaleFerretsGene DeletionGene EditingGene Expression Regulation, DevelopmentalGene Knockout TechniquesGerm-Line MutationHumansMaleMiceMicrocephalyNerve Tissue ProteinsNeural Stem CellsOrgan SizeTranscription, GeneticConceptsVentricular radial glial cellsEvolutionary mechanismsRadial glial cellsOuter radial gliaHuman primary microcephalyProtein sequence homologyAbnormal spindle-like microcephalyCerebral cortical sizeGlial cellsCortical sizeUndifferentiated cell typesNeural progenitor cellsRadial gliaASPM proteinCerebral cortical expansionMicrocephaly genesDivergent functionsGenome editingSequence homologyDifferentiated progenitorsOuter subventricular zoneCortical expansionPrimary microcephalyCell typesGermline knockout
2014
Diffusion Tensor Imaging as a Predictor of Locomotor Function after Experimental Spinal Cord Injury and Recovery
Kelley BJ, Harel NY, Kim CY, Papademetris X, Coman D, Wang X, Hasan O, Kaufman A, Globinsky R, Staib LH, Cafferty WB, Hyder F, Strittmatter SM. Diffusion Tensor Imaging as a Predictor of Locomotor Function after Experimental Spinal Cord Injury and Recovery. Journal Of Neurotrauma 2014, 31: 1362-1373. PMID: 24779685, PMCID: PMC4120934, DOI: 10.1089/neu.2013.3238.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDiffusion tensor imagingCord injuryAxonal integrityLocomotor functionExperimental spinal cord injuryTraumatic spinal cord injuryFemale Sprague-Dawley ratsTensor imagingFractional anisotropyFunctional recovery assessmentSpinal cord contusionLimited functional recoveryLong-term disabilityQuantitative diffusion tensor imagingRodent SCI modelsSprague-Dawley ratsSpinal cord morphologyWhite matter pathologyCaudal spinal cordWhite matter integrityInjury epicenterMidthoracic laminectomyCord contusionPrimary outcome
2009
DTI abnormalities in anterior corpus callosum of rats with spike–wave epilepsy
Chahboune H, Mishra AM, DeSalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X, Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H. DTI abnormalities in anterior corpus callosum of rats with spike–wave epilepsy. NeuroImage 2009, 47: 459-466. PMID: 19398019, PMCID: PMC2712639, DOI: 10.1016/j.neuroimage.2009.04.060.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus CallosumDiffusion Magnetic Resonance ImagingDisease Models, AnimalEpilepsy, AbsenceFemaleHumansNerve Fibers, MyelinatedRatsRats, WistarConceptsSpike-wave dischargesDiffusion tensor imagingAnterior corpus callosumWAG/RijFractional anisotropyWhite matter pathwaysSeizure activityAbsence epilepsyCorpus callosumDTI abnormalitiesEpileptic WAG/Rij ratsWAG/Rij ratsGenetic Absence Epilepsy RatsCallosal fractional anisotropySomatosensory cortex regionSpike-wave epilepsyBilateral spike-wave dischargesCommon seizure disorderWistar albino Glaxo ratsGlaxo ratsChronic seizuresEpileptic animalsNonepileptic controlsSeizure disorderNeurological difficulties