Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, Staib LH, Charney DS, Bremner JD. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry 2004, 56: 101-112. PMID: 15231442, DOI: 10.1016/j.biopsych.2004.04.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderUrinary free cortisolHippocampal volumeHealthy subjectsMemory deficitsDepressed patientsDepressive disorderCortisol statusSelective serotonin reuptake inhibitor (SSRI) treatmentSerotonin reuptake inhibitor treatmentWechsler Memory Scale-RevisedNormal hippocampal volumesReuptake inhibitor treatmentWhole hippocampal volumeWhole brain volumeDeclarative memory deficitsEffect of treatmentMemory functionDeclarative memory functionUFC excretionAntidepressant treatmentFree cortisolHippocampal dysfunctionBaseline plasmaSuccessful treatment