2012
Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
Pangilinan F, Molloy AM, Mills JL, Troendle JF, Parle-McDermott A, Signore C, O’Leary V, Chines P, Seay JM, Geiler-Samerotte K, Mitchell A, VanderMeer JE, Krebs KM, Sanchez A, Cornman-Homonoff J, Stone N, Conley M, Kirke PN, Shane B, Scott JM, Brody LC. Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects. BMC Medical Genomics 2012, 13: 62. PMID: 22856873, PMCID: PMC3458983, DOI: 10.1186/1471-2350-13-62.Peer-Reviewed Original ResearchConceptsStrongest association signalAssociation signalsCandidate genesNTD mouse modelsSingle strong signalHigh-priority candidatesCommon genetic variantsMaternal periconceptional folic acid supplementationNTD riskGenetic association studiesCommon birth defectsPathway genesList of variantsB12 pathwayFolate metabolic pathwayAssociation studiesMaternal effectsMetabolic pathwaysGenesPriority candidatesGenetic variantsCommon variationTube defectsCandidate polymorphismsSNPs
2011
Heavy prenatal alcohol exposure and risk of stillbirth and preterm delivery
Cornman-Homonoff J, Kuehn D, Aros S, Carter TC, Conley MR, Troendle J, Cassorla F, Mills JL. Heavy prenatal alcohol exposure and risk of stillbirth and preterm delivery. The Journal Of Maternal-Fetal & Neonatal Medicine 2011, 25: 860-863. PMID: 21728738, PMCID: PMC4148070, DOI: 10.3109/14767058.2011.587559.Peer-Reviewed Original ResearchConceptsPreterm deliveryStillbirth rateDrinks/dayRisk of stillbirthPrenatal alcohol useHeavy alcohol consumptionPrenatal alcohol exposureHeavy prenatal alcohol exposurePreterm birthPreterm ratePregnant womenAlcohol exposureAlcohol consumptionStillbirthAlcohol useWomenPopulation ratesAdditional investigationRiskDeliveryPregnancy