2010
Adolescent Maturation of D1 and D2 Dopamine Receptor Interactions
Dwyer J, Martinez L, Ganddini G, Perez M, Leslie F. Adolescent Maturation of D1 and D2 Dopamine Receptor Interactions. The FASEB Journal 2010, 24: 766.1-766.1. DOI: 10.1096/fasebj.24.1_supplement.766.1.Peer-Reviewed Original ResearchD1/D2 interactionsDopamine receptor interactionsMesocorticolimbic dopamine systemImmediate early gene expressionDopaminergic drugsReceptor changesD2 agonistDirect agonistsIndirect agonistsAdult ratsLimbic systemDopamine systemDirect D1Neuropsychiatric disordersEarly gene expressionFunctional connectivityNeural circuitryDA systemBehavioral responsesAgonistsC-fosAge differencesPhRMA FoundationAdolescent maturationReceptor interaction
2009
The dynamic effects of nicotine on the developing brain
Dwyer JB, McQuown SC, Leslie FM. The dynamic effects of nicotine on the developing brain. Pharmacology & Therapeutics 2009, 122: 125-139. PMID: 19268688, PMCID: PMC2746456, DOI: 10.1016/j.pharmthera.2009.02.003.Peer-Reviewed Original ResearchConceptsNicotine exposureDevelopmental influencesAdolescent periodBrain maturationExogenous nicotineHuman brainUnique effectsMaturational periodNeural structuresLimbic systemClinical literatureNicotine replacement therapyEnvironmental stimuliEarly postnatal periodPreclinical animal modelsDevelopmental windowNicotinic acetylcholine receptorsPrenatal periodReplacement therapyEarly postnatalPostnatal periodTobacco smokeAnimal modelsAcetylcholine receptorsNicotine