2023
Outcomes of Treatment With Neoadjuvant Cemiplimab for Patients With Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck
Ferrarotto R, Nagarajan P, Maronge J, Johnson J, Rosenthal D, Myers J, Gross N. Outcomes of Treatment With Neoadjuvant Cemiplimab for Patients With Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck. JAMA Otolaryngology - Head & Neck Surgery 2023, 149: 847-849. PMID: 37535378, PMCID: PMC10401391, DOI: 10.1001/jamaoto.2023.1729.Peer-Reviewed Original Research
2022
Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study
Ng S, Cardenas C, Bahig H, Elgohari B, Wang J, Johnson J, Moreno A, Shah S, Garden A, Phan J, Gunn G, Frank S, Ding Y, Na L, Yuan Y, Urbauer D, Mohamed A, Rosenthal D, Morrison W, MacManus M, Fuller C. Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study. Current Oncology 2022, 29: 6303-6313. PMID: 36135064, PMCID: PMC9498049, DOI: 10.3390/curroncol29090495.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficientPost-treatment MRIT3-T4 tumorsIntact primary tumorSquamous cell carcinomaT1-T2 tumorsDifferent treatment responsesNodal diseaseOropharyngeal cancerClinical featuresSpearman correlation coefficientCell carcinomaNeck cancerPrimary tumorNeck radiotherapyNodal sitesTreatment responseWeek 4Weekly MRIPatientsMR biomarkersGTV sizeNodal volumeADC valuesTumors
2019
Surveillance imaging for patients with head and neck cancer treated with definitive radiotherapy: A partially observed Markov decision process model
Ng S, Ajayi T, Schaefer A, Pollard C, Bahig H, Garden A, Rosenthal D, Gunn G, Frank S, Phan J, Morrison W, Johnson J, Mohamed A, Sturgis E, Fuller C. Surveillance imaging for patients with head and neck cancer treated with definitive radiotherapy: A partially observed Markov decision process model. Cancer 2019, 126: 749-756. PMID: 31725906, PMCID: PMC8439665, DOI: 10.1002/cncr.32597.Peer-Reviewed Original ResearchUsefulness of surveillance imaging in patients with head and neck cancer who are treated with definitive radiotherapy
Ng S, Pollard C, Berends J, Ayoub Z, Kamal M, Garden A, Bahig H, Cantor S, Schaefer A, Ajayi T, Gunn G, Frank S, Skinner H, Phan J, Morrison W, Ferrarotto R, Johnson J, Mohamed A, Lai S, Hessel A, Sturgis E, Weber R, Fuller C, Rosenthal D. Usefulness of surveillance imaging in patients with head and neck cancer who are treated with definitive radiotherapy. Cancer 2019, 125: 1823-1829. PMID: 30748005, PMCID: PMC7234834, DOI: 10.1002/cncr.31983.Peer-Reviewed Original ResearchConceptsDisease recurrenceAsymptomatic patientsOverall survivalClinical findingsNeck cancerAdverse clinical findingsLocoregional disease recurrenceMedian imaging followUsefulness of surveillanceDisease-free intervalMedian overall survivalDistant disease recurrenceGroup of patientsEfficacy of surveillanceTreatment of HNCEligible patientsSalvage therapySalvageable recurrenceDefinitive radiotherapyMedian timeSuspicious findingsPatientsRecurrenceRadiotherapyEarly detection
2018
Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching ‘liquid biopsy’ and quantitative tumor modeling
Ng S, Bahig H, Wang J, Cardenas C, Lucci A, Hall C, Meas S, Sarli V, Yuan Y, Urbauer D, Ding Y, Ikner S, Dinh V, Elgohari B, Johnson J, Skinner H, Gunn G, Garden A, Phan J, Rosenthal D, Morrison W, Frank S, Hutcheson K, Mohamed A, Lai S, Ferrarotto R, MacManus M, Fuller C. Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching ‘liquid biopsy’ and quantitative tumor modeling. BMC Cancer 2018, 18: 903. PMID: 30231854, PMCID: PMC6148797, DOI: 10.1186/s12885-018-4808-5.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersClinical ProtocolsFemaleHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedImaging, Three-DimensionalLiquid BiopsyMagnetic Resonance ImagingMaleNeoplastic Cells, CirculatingPositron Emission Tomography Computed TomographyPositron-Emission TomographyPrognosisProspective StudiesTreatment OutcomeConceptsNeck cancerPET/CT imagesTreatment responseBlood samplesTumor cellsTumor cell measurementUtility of CTCsProspective observational studyBackgroundMagnetic resonance imagingSoft tissue involvementDate of enrollmentSerial MR imagingDe-escalation strategiesPersonalization of treatmentEDTA blood samplesCirculating Tumor CellsCTC assessmentMucosal headClinical outcomesDose escalationImaging changesLocal therapyPretreatment CTPatient selectionPrognostic valueSignificance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer
Ng S, Johnson J, Gunn G, Rosenthal D, Skinner H, Phan J, Frank S, Morrison W, Sturgis E, Mott F, Williams M, Fuller C, Garden A. Significance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: 1029-1035. PMID: 29960060, PMCID: PMC9620951, DOI: 10.1016/j.ijrobp.2018.06.031.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaComplete metabolic responseDisease-free survivalOverall survival rateSquamous cell carcinomaCell carcinomaTomography scanSurvival rateHPV-positive oropharyngeal cancerCommon primary siteHPV/p16Posttreatment PET imagingPosttreatment PET scansKaplan-Meier methodSubgroup of patientsBase of tongueGroup of patientsHuman papilloma virusDevelopment of recurrencePET/CT imagingMetabolic responseOptimal surveillance strategyPositron emission tomographyLonger life expectancyEleven patientsThree-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer
Kamal M, Ng S, Eraj S, Rock C, Pham B, Messer J, Garden A, Morrison W, Phan J, Frank S, El-Naggar A, Johnson J, Ginsberg L, Ferrarotto R, Lewin J, Hutcheson K, Cardenas C, Zafereo M, Lai S, Hessel A, Weber R, Gunn G, Fuller C, Mohamed A, Rosenthal D. Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer. Oral Oncology 2018, 79: 1-8. PMID: 29598944, PMCID: PMC5880303, DOI: 10.1016/j.oraloncology.2018.01.025.Peer-Reviewed Original ResearchConceptsTumor volumeOverall survivalLocal controlSurvival outcomesLimited invasionExtent of invasionLarynx cancerPrimary gross tumor volumeGood performance statusPoor local controlT3 laryngeal carcinomaImproved overall survivalLaryngeal carcinoma patientsMedian tumor volumeOverall survival rateIndependent prognostic factorPretreatment contrast-enhanced computed tomography imagesPrimary tumor invasionContrast-enhanced computed tomography imagesSoft tissue involvementLaryngeal preservation strategiesGross tumor volumeDefinitive radiotherapyExtent of involvementLaryngeal preservation
2017
Cognitive function and patient‐reported memory problems after radiotherapy for cancers at the skull base: A cross‐sectional survivorship study using the Telephone Interview for Cognitive Status and the MD Anderson Symptom Inventory‐Head and Neck Module
Hansen C, Smith J, Mohamed A, Mulcahy C, Wefel J, Hutcheson K, Chrane K, Phan J, Frank S, Garden A, Smith B, Eichelberger H, Anderson C, McCoy C, Horiates M, Patrick C, Floris S, French C, Beadle B, Morrison W, Su S, Lewis C, Kupferman M, Johnson J, Skinner H, Lai S, Hanna E, Rosenthal D, Fuller C, Gunn G, Group A. Cognitive function and patient‐reported memory problems after radiotherapy for cancers at the skull base: A cross‐sectional survivorship study using the Telephone Interview for Cognitive Status and the MD Anderson Symptom Inventory‐Head and Neck Module. Head & Neck 2017, 39: 2048-2056. PMID: 28763137, PMCID: PMC6082378, DOI: 10.1002/hed.24876.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedArea Under CurveCentral Nervous SystemCognitionCognitive DysfunctionCross-Sectional StudiesFemaleHealth Status IndicatorsHumansInterviews as TopicMaleMass ScreeningMemory DisordersMiddle AgedPatient Reported Outcome MeasuresRadiation InjuriesSeverity of Illness IndexSkull BaseSkull Base NeoplasmsSurvivorshipYoung AdultConceptsMD Anderson Symptom Inventory-HeadDetectable cognitive impairmentCognitive dysfunctionCognitive impairmentNeck ModuleCognitive statusTelephone interviewsPatient-reported problemsThird of patientsSkull base cancerRecursive partition analysisObjective assessment toolCognitive symptomsCutoff pointSkull baseCognitive functionSurvivorship studiesScreening toolMemory complaintsObjective cognitive dysfunctionImpairmentSevere levelsMDASIPatientsDysfunctionQuantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx
Shiao J, Mohamed A, Messer J, Hutcheson K, Johnson J, Enderling H, Kamal M, Warren B, Pham B, Morrison W, Zafereo M, Hessel A, Lai S, Kies M, Ferrarotto R, Garden A, Schomer D, Gunn G, Phan J, Frank S, Beadle B, Weber R, Lewin J, Rosenthal D, Fuller C. Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx. Head & Neck 2017, 39: 1609-1620. PMID: 28464542, PMCID: PMC5511768, DOI: 10.1002/hed.24804.Peer-Reviewed Original ResearchConceptsT4a laryngeal cancerSquamous cell carcinomaTumor volumeOverall survivalLaryngeal cancerFive-year overall survivalWorse disease-specific survivalLaryngeal squamous cell carcinomaFive-year OSCause-specific survivalDisease-specific survivalEvent-free survivalIndependent prognostic factorRecurrence-free survivalPrimary tumor volumeSignificant independent correlatesTumor volume measurementsLarynx preservationOncologic outcomesPrognostic factorsPretreatment CTSquamous carcinomaCell carcinomaIndependent correlatesTotal laryngectomy