Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching ‘liquid biopsy’ and quantitative tumor modeling
Ng S, Bahig H, Wang J, Cardenas C, Lucci A, Hall C, Meas S, Sarli V, Yuan Y, Urbauer D, Ding Y, Ikner S, Dinh V, Elgohari B, Johnson J, Skinner H, Gunn G, Garden A, Phan J, Rosenthal D, Morrison W, Frank S, Hutcheson K, Mohamed A, Lai S, Ferrarotto R, MacManus M, Fuller C. Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching ‘liquid biopsy’ and quantitative tumor modeling. BMC Cancer 2018, 18: 903. PMID: 30231854, PMCID: PMC6148797, DOI: 10.1186/s12885-018-4808-5.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersClinical ProtocolsFemaleHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedImaging, Three-DimensionalLiquid BiopsyMagnetic Resonance ImagingMaleNeoplastic Cells, CirculatingPositron Emission Tomography Computed TomographyPositron-Emission TomographyPrognosisProspective StudiesTreatment OutcomeConceptsNeck cancerPET/CT imagesTreatment responseBlood samplesTumor cellsTumor cell measurementUtility of CTCsProspective observational studyBackgroundMagnetic resonance imagingSoft tissue involvementDate of enrollmentSerial MR imagingDe-escalation strategiesPersonalization of treatmentEDTA blood samplesCirculating Tumor CellsCTC assessmentMucosal headClinical outcomesDose escalationImaging changesLocal therapyPretreatment CTPatient selectionPrognostic valueSignificance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer
Ng S, Johnson J, Gunn G, Rosenthal D, Skinner H, Phan J, Frank S, Morrison W, Sturgis E, Mott F, Williams M, Fuller C, Garden A. Significance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: 1029-1035. PMID: 29960060, PMCID: PMC9620951, DOI: 10.1016/j.ijrobp.2018.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCyclin-Dependent Kinase Inhibitor p16FemaleFluorodeoxyglucose F18HumansMaleMiddle AgedOropharyngeal NeoplasmsPapillomaviridaePositron Emission Tomography Computed TomographyRetrospective StudiesConceptsOropharyngeal squamous cell carcinomaComplete metabolic responseDisease-free survivalOverall survival rateSquamous cell carcinomaCell carcinomaTomography scanSurvival rateHPV-positive oropharyngeal cancerCommon primary siteHPV/p16Posttreatment PET imagingPosttreatment PET scansKaplan-Meier methodSubgroup of patientsBase of tongueGroup of patientsHuman papilloma virusDevelopment of recurrencePET/CT imagingMetabolic responseOptimal surveillance strategyPositron emission tomographyLonger life expectancyEleven patients