2022
Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study
Ng S, Cardenas C, Bahig H, Elgohari B, Wang J, Johnson J, Moreno A, Shah S, Garden A, Phan J, Gunn G, Frank S, Ding Y, Na L, Yuan Y, Urbauer D, Mohamed A, Rosenthal D, Morrison W, MacManus M, Fuller C. Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI during Radiotherapy in Patients with Head and Neck Cancer: Results from the PREDICT-HN Study. Current Oncology 2022, 29: 6303-6313. PMID: 36135064, PMCID: PMC9498049, DOI: 10.3390/curroncol29090495.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficientPost-treatment MRIT3-T4 tumorsIntact primary tumorSquamous cell carcinomaT1-T2 tumorsDifferent treatment responsesNodal diseaseOropharyngeal cancerClinical featuresSpearman correlation coefficientCell carcinomaNeck cancerPrimary tumorNeck radiotherapyNodal sitesTreatment responseWeek 4Weekly MRIPatientsMR biomarkersGTV sizeNodal volumeADC valuesTumors
2019
Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy
Ng S, Pollard C, Kamal M, Ayoub Z, Garden A, Bahig H, Gunn G, Frank S, Skinner H, Phan J, Berends J, Morrison W, Johnson J, Ferrarotto R, Sturgis E, Mohamed A, Lai S, Fuller C, Rosenthal D. Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy. Npj Precision Oncology 2019, 3: 22. PMID: 31583278, PMCID: PMC6764977, DOI: 10.1038/s41698-019-0097-y.Peer-Reviewed Original ResearchSecond primary malignanciesDefinitive radiotherapyFormer smokersCurrent smokersOverall survivalPrimary malignancyRisk of SPMCurative-intent therapyIndex oropharyngeal cancersCompletion of radiotherapySignificant smoking historyKaplan-Meier methodMajority of patientsNeck cancer patientsSame risk factorsNeck cancer treatmentEligible patientsSPM ratesPack yearsSmoking historyOropharyngeal cancerInvasive cancerCancer patientsRisk factorsClinical data