2019
Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy
Ng S, Pollard C, Kamal M, Ayoub Z, Garden A, Bahig H, Gunn G, Frank S, Skinner H, Phan J, Berends J, Morrison W, Johnson J, Ferrarotto R, Sturgis E, Mohamed A, Lai S, Fuller C, Rosenthal D. Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy. Npj Precision Oncology 2019, 3: 22. PMID: 31583278, PMCID: PMC6764977, DOI: 10.1038/s41698-019-0097-y.Peer-Reviewed Original ResearchSecond primary malignanciesDefinitive radiotherapyFormer smokersCurrent smokersOverall survivalPrimary malignancyRisk of SPMCurative-intent therapyIndex oropharyngeal cancersCompletion of radiotherapySignificant smoking historyKaplan-Meier methodMajority of patientsNeck cancer patientsSame risk factorsNeck cancer treatmentEligible patientsSPM ratesPack yearsSmoking historyOropharyngeal cancerInvasive cancerCancer patientsRisk factorsClinical data
2018
Significance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer
Ng S, Johnson J, Gunn G, Rosenthal D, Skinner H, Phan J, Frank S, Morrison W, Sturgis E, Mott F, Williams M, Fuller C, Garden A. Significance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: 1029-1035. PMID: 29960060, PMCID: PMC9620951, DOI: 10.1016/j.ijrobp.2018.06.031.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaComplete metabolic responseDisease-free survivalOverall survival rateSquamous cell carcinomaCell carcinomaTomography scanSurvival rateHPV-positive oropharyngeal cancerCommon primary siteHPV/p16Posttreatment PET imagingPosttreatment PET scansKaplan-Meier methodSubgroup of patientsBase of tongueGroup of patientsHuman papilloma virusDevelopment of recurrencePET/CT imagingMetabolic responseOptimal surveillance strategyPositron emission tomographyLonger life expectancyEleven patients