Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy
Ng S, Pollard C, Kamal M, Ayoub Z, Garden A, Bahig H, Gunn G, Frank S, Skinner H, Phan J, Berends J, Morrison W, Johnson J, Ferrarotto R, Sturgis E, Mohamed A, Lai S, Fuller C, Rosenthal D. Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy. Npj Precision Oncology 2019, 3: 22. PMID: 31583278, PMCID: PMC6764977, DOI: 10.1038/s41698-019-0097-y.Peer-Reviewed Original ResearchSecond primary malignanciesDefinitive radiotherapyFormer smokersCurrent smokersOverall survivalPrimary malignancyRisk of SPMCurative-intent therapyIndex oropharyngeal cancersCompletion of radiotherapySignificant smoking historyKaplan-Meier methodMajority of patientsNeck cancer patientsSame risk factorsNeck cancer treatmentEligible patientsSPM ratesPack yearsSmoking historyOropharyngeal cancerInvasive cancerCancer patientsRisk factorsClinical data