Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer
Kamal M, Ng S, Eraj S, Rock C, Pham B, Messer J, Garden A, Morrison W, Phan J, Frank S, El-Naggar A, Johnson J, Ginsberg L, Ferrarotto R, Lewin J, Hutcheson K, Cardenas C, Zafereo M, Lai S, Hessel A, Weber R, Gunn G, Fuller C, Mohamed A, Rosenthal D. Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer. Oral Oncology 2018, 79: 1-8. PMID: 29598944, PMCID: PMC5880303, DOI: 10.1016/j.oraloncology.2018.01.025.Peer-Reviewed Original ResearchConceptsTumor volumeOverall survivalLocal controlSurvival outcomesLimited invasionExtent of invasionLarynx cancerPrimary gross tumor volumeGood performance statusPoor local controlT3 laryngeal carcinomaImproved overall survivalLaryngeal carcinoma patientsMedian tumor volumeOverall survival rateIndependent prognostic factorPretreatment contrast-enhanced computed tomography imagesPrimary tumor invasionContrast-enhanced computed tomography imagesSoft tissue involvementLaryngeal preservation strategiesGross tumor volumeDefinitive radiotherapyExtent of involvementLaryngeal preservation