Merkel Cell Polyomavirus Expression in Merkel Cell Carcinomas and Its Absence in Combined Tumors and Pulmonary Neuroendocrine Carcinomas
Busam KJ, Jungbluth AA, Rekthman N, Coit D, Pulitzer M, Bini J, Arora R, Hanson NC, Tassello JA, Frosina D, Moore P, Chang Y. Merkel Cell Polyomavirus Expression in Merkel Cell Carcinomas and Its Absence in Combined Tumors and Pulmonary Neuroendocrine Carcinomas. The American Journal Of Surgical Pathology 2009, 33: 1378-1385. PMID: 19609205, PMCID: PMC2932664, DOI: 10.1097/pas.0b013e3181aa30a5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkers, TumorCarcinoma, Merkel CellCarcinoma, Squamous CellCell CountDNA, NeoplasmDNA, ViralFemaleFluorescent Antibody Technique, DirectHumansKeratin-20Lung NeoplasmsLymph NodesMaleMiddle AgedPolymerase Chain ReactionPolyomavirusPolyomavirus InfectionsSkin NeoplasmsTissue Array AnalysisTumor Virus InfectionsConceptsMerkel cell carcinomaPulmonary neuroendocrine carcinomasMerkel cell polyomavirusMajority of MCCsNeuroendocrine carcinomaCell carcinomaPolymerase chain reactionDiagnosis of MCCPrimary cutaneous neuroendocrine carcinomaCutaneous neuroendocrine carcinomaSquamous cell carcinomaChain reactionFrozen tumor samplesMCV T antigenQuantitative polymerase chain reactionCytokeratin 20Frozen tissue samplesTissue microarrayCombined tumorCarcinomaNeuroendocrine phenotypeLarge T antigen geneImmunohistochemistryTumor samplesCM2B4