2018
Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet
Rutkowsky JM, Lee LL, Puchowicz M, Golub MS, Befroy DE, Wilson DW, Anderson S, Cline G, Bini J, Borkowski K, Knotts TA, Rutledge JC, . Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet. PLOS ONE 2018, 13: e0191909. PMID: 29444171, PMCID: PMC5812615, DOI: 10.1371/journal.pone.0191909.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierBrainCognitionDiet, WesternMiceMice, Inbred C57BLMice, KnockoutReceptors, LDLConceptsWestern dietBrain metabolismCognitive functionC57BL/6 miceBarrier transportLow-density lipoprotein receptor-null miceBlood-brain barrier transportLDLR-/- miceReceptor null miceModel of hyperlipidemiaRadial arm water mazeProinflammatory lipid mediatorsIndicator of activationBBB transportInflammatory responseLipid levelsMetabolic assessmentLipid mediatorsWhole mouse brainWater mazeCognitive declineCognitive impairmentMouse brainBrain metabolitesNull mice
2016
In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models
Pérez-Medina C, Binderup T, Lobatto ME, Tang J, Calcagno C, Giesen L, Wessel CH, Witjes J, Ishino S, Baxter S, Zhao Y, Ramachandran S, Eldib M, Sánchez-Gaytán BL, Robson PM, Bini J, Granada JF, Fish KM, Stroes ES, Duivenvoorden R, Tsimikas S, Lewis JS, Reiner T, Fuster V, Kjær A, Fisher EA, Fayad ZA, Mulder WJ. In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models. JACC Cardiovascular Imaging 2016, 9: 950-961. PMID: 27236528, PMCID: PMC5589956, DOI: 10.1016/j.jcmg.2016.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisAutoradiographyDisease Models, AnimalFemaleFlow CytometryLipoproteins, HDLMagnetic Resonance ImagingMaleMice, Inbred C57BLMice, KnockoutMolecular ImagingOptical ImagingPlaque, AtheroscleroticPositron Emission Tomography Computed TomographyPredictive Value of TestsRabbitsRadioisotopesRadiopharmaceuticalsReproducibility of ResultsTissue DistributionZirconiumConceptsHigh-density lipoproteinPositron emission tomographyHDL nanoparticlesPlaque macrophagesPET imagingAtherosclerotic plaque macrophagesRadioactivity uptake valuesIncident cardiovascular eventsCoronary heart diseaseDistinct pharmacokinetic profileStrong independent predictorHDL cholesterol concentrationsReverse cholesterol transportAdvanced atherosclerotic lesionsAccumulation of radioactivityMagnetic resonance imagingVivo PET imagingNoninvasive imaging toolNoninvasive PET imagingCardiovascular eventsIndependent predictorsAtherosclerosis modelHeart diseaseMurine modelAtherosclerotic lesions