2024
Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project
Sajatovic M, Rej S, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Beunders A, Blumberg H, Briggs F, Dols A, Forester B, Forlenza O, Gildengers A, Jimenez E, Klaus F, Lafer B, Mulsant B, Mwangi B, Nunes P, Olagunju A, Oluwaniyi S, Orhan M, Patrick R, Radua J, Rajji T, Sarna K, Schouws S, Simhandl C, Sekhon H, Soares J, Sutherland A, Teixeira A, Tsai S, Vidal‐Rubio S, Vieta E, Yala J, Eyler L. Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project. International Journal Of Geriatric Psychiatry 2024, 39: e6057. PMID: 38511929, DOI: 10.1002/gps.6057.Peer-Reviewed Original ResearchMeSH KeywordsAgedAgingBipolar DisorderDatabases, FactualFemaleHumansMaleManiaMedically Unexplained SymptomsMiddle AgedConceptsOlder age bipolar disorderBipolar Disorder DatabaseSomatic burdenBipolar disorderGAGE-BDAssociated with worse functionSymptom severityBD symptomsAssociated with depression severityOlder-age bipolar disorderGlobal Aging & Geriatric ExperimentsManic symptom severityAssociated with poorer functioningGeriatric experiencesAssociation of depressionBipolar symptomsSevere maniaDepression severityDepressive symptomsLow functioningSomatic conditionsPoor functionWorse functionArchival datasetWave 2
2022
Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorder
Forlenza OV, Hajek T, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, De‐Paula V, Dols A, Eyler LT, Forester BP, Gildengers A, Jimenez E, Korten NCM, Lafer B, McWhinney SR, Mulsant B, Rej S, Sarna K, Schouws S, Sutherland A, Tsai S, Vieta E, Yala J, Sajatovic M, initiative G. Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorder. Acta Psychiatrica Scandinavica 2022, 146: 442-455. PMID: 35837985, PMCID: PMC9588573, DOI: 10.1111/acps.13474.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntipsychotic AgentsBipolar DisorderDemographyFemaleHumansLithiumLithium CompoundsMaleMiddle AgedConceptsLithium usersBipolar disorderClinical characteristicsOlder adultsDepression Rating ScaleCross-sectional analysisGlobal cognitive stateCardiovascular comorbiditiesCross-sectional approachClinical profileMood stabilizersLithium therapySevere depressionPsychiatric diagnosisRating ScaleCurrent prescriptionGlobal AGEingDisordersRapid cyclingAdultsRelevant differencesSafety concernsLower scoresCurrent useMethodological limitationsDemographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).
Chen P, Eyler LT, Gildengers A, Beunders AJ, Blumberg HP, Briggs FB, Dols A, Rej S, Forlenza OV, Jimenez E, Mulsant B, Schouws S, Orhan M, Sarna K, Sutherland AN, Vieta E, Tsai S, Yala J, Villa LM, Sajatovic M. Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). Psychopharmacology Bulletin 2022, 52: 8-33. PMID: 35721813, PMCID: PMC9172555.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderFirst-generation antipsychoticsAntipsychotic drugsBipolar disorderPsychiatric hospitalizationMean age 63.2 yearsGlobal AGEingClinical characteristicsFrequent hospitalizationsClinical variablesSevere illnessTreatment statusGreater burdenHospitalizationDisorder databaseOlder adultsCross-sectional dataLongitudinal outcomesDisordersPatientsGeneralized mixed modelMultivariate model resultsInternational studiesDrugsObservational analysisCognition in older adults with bipolar disorder: An ISBD task force systematic review and meta‐analysis based on a comprehensive neuropsychological assessment
Montejo L, Torrent C, Jiménez E, Martínez‐Arán A, Blumberg HP, Burdick KE, Chen P, Dols A, Eyler LT, Forester BP, Gatchel JR, Gildengers A, Kessing LV, Miskowiak KW, Olagunju AT, Patrick RE, Schouws S, Radua J, del M. Bonnín C, Vieta E, Force I. Cognition in older adults with bipolar disorder: An ISBD task force systematic review and meta‐analysis based on a comprehensive neuropsychological assessment. Bipolar Disorders 2022, 24: 115-136. PMID: 34978124, DOI: 10.1111/bdi.13175.Peer-Reviewed Original ResearchConceptsComprehensive neuropsychological assessmentNeuropsychological assessmentCognitive domainsExecutive functionProcessing speedAttention/processing speedOlder adultsDetailed neuropsychological profileEuthymic older adultsComplete neuropsychological assessmentEffect sizeModerate effect sizeCognitive flexibilityVerbal learningMemory domainImmediate memoryVerbal fluencyCognitive performanceNeuropsychological profileOABD patientsSignificant effect sizeBipolar disorderCognitive functionOABDLarge significant effect sizes
2021
Bipolar symptoms, somatic burden, and functioning in older‐age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project
Sajatovic M, Dols A, Rej S, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, Forester BP, Patrick RE, Forlenza OV, Gildengers A, Jimenez E, Vieta E, Mulsant B, Schouws S, Paans N, Strejilevich S, Sutherland A, Tsai S, Wilson B, Eyler LT. Bipolar symptoms, somatic burden, and functioning in older‐age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project. Bipolar Disorders 2021, 24: 195-206. PMID: 34314549, PMCID: PMC8792096, DOI: 10.1111/bdi.13119.Peer-Reviewed Original Research
2003
Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder
Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder. JAMA Psychiatry 2003, 60: 1201-1208. PMID: 14662552, DOI: 10.1001/archpsyc.60.12.1201.Peer-Reviewed Original ResearchConceptsHippocampal volumeMedial temporal lobe structuresTemporal lobe structuresBipolar disorderIllness featuresVeterans Affairs Medical CenterLobe structuresRepeated-measures statistical analysisCourse of illnessTotal brain volumeAmygdala volume reductionsBD type IAnatomic magnetic resonanceHealthy comparison subjectsPaucity of dataVolume reductionSignificant volume reductionVolumetric abnormalitiesNeurodegenerative changesIllness durationOutpatient treatmentUniversity HospitalGreater effect sizeMedical CenterHippocampal regionA Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices
Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices. JAMA Psychiatry 2003, 60: 601-609. PMID: 12796223, DOI: 10.1001/archpsyc.60.6.601.Peer-Reviewed Original ResearchConceptsVentral prefrontal cortexBipolar disorderPrefrontal cortexMood statesMagnetic resonance imaging studyHealthy control subjectsAcute mood statesLeft ventral prefrontal cortexResonance imaging studySignal changesDisturbances of attentionFunctional magnetic resonance imaging studyAnterior cingulate cortexBipolar disorder IDorsal anterior cingulateEvent-related functional magnetic resonanceFunctional magnetic resonanceAcute episodeControl subjectsExaggerated increaseFunctional impairmentBlunted activationMood episodesSpecific mood statesPrefrontal abnormalities
2001
Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression
de Asis J, Stern E, Alexopoulos G, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eidelberg D, Kiosses D, Silbersweig D. Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression. American Journal Of Psychiatry 2001, 158: 1321-1323. PMID: 11481171, DOI: 10.1176/appi.ajp.158.8.1321.Peer-Reviewed Original ResearchConceptsGeriatric depressionActivation deficitsComparison subjectsDorsal anterior cingulate gyrusPositron emission tomography scanEmission tomography scanDepressed geriatric patientsAnterior cingulate gyrusHealthy comparison subjectsElderly patientsGeriatric patientsFrontotemporal functionHippocampal dysfunctionTomography scanPrevalent disorderCingulate gyrusMemory dysfunctionWord generation taskPatientsMemory deficitsHippocampal activityActivation paradigmNeural substratesDepressionDysfunction
2000
Increased anterior cingulate and caudate activity in bipolar mania
Blumberg H, Stern E, Martinez D, Ricketts S, de Asis J, White T, Epstein J, McBride P, Eidelberg D, Kocsis J, Silbersweig D. Increased anterior cingulate and caudate activity in bipolar mania. Biological Psychiatry 2000, 48: 1045-1052. PMID: 11094137, DOI: 10.1016/s0006-3223(00)00962-8.Peer-Reviewed Original ResearchConceptsManic stateAnterior cingulateBipolar disorderHead of caudateFunctional brain abnormalitiesPositron emission tomography techniquesDorsal anterior cingulateEmission tomography techniquesBipolar maniaBrain abnormalitiesSuch dysfunctionCingulateDisordersBrain activityCaudate activityCaudateManiaNeural systemsPrincipal findingsDysfunctionActivityAbnormalitiesEuthymiaExecutive controlFindings
1990
General assay for phosphoproteins in cerebrospinal fluid: A candidate market for paraneoplastic cerebellar degeneration
Gandy S, Grebb J, Rosen N, Albert K, Devinsky O, Blumberg H, Anderson N, Cedarbaum J, Porter R, Sedvall G, Posner J, Greengard P. General assay for phosphoproteins in cerebrospinal fluid: A candidate market for paraneoplastic cerebellar degeneration. Annals Of Neurology 1990, 28: 829-833. PMID: 2285268, DOI: 10.1002/ana.410280616.Peer-Reviewed Original ResearchConceptsProtein kinase C substrate proteinProtein kinase substratesProtein phosphorylation systemsSubstrate proteinsKinase substratePhosphorylation systemBiochemical characterizationCell typesPhosphoproteinNeuronal cellsNeuronal diseasesNeuronal enrichmentGeneral assayUnique markerPotential insightsNeuronal populationsProteinNeurological diseasesCerebellar degenerationCellsAssaysEnrichmentAssay techniquesKdMarkers