2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder
Johnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderWhite matter integrityFunctional connectivityMatter volumeSuicide attemptsAttempt lethalityPrefrontal connectivitySuicidal ideationYoung adult suicide attemptersAmygdala-prefrontal functional connectivityYoung adultsAmygdala functional connectivitySuicide-related symptomsAdult suicide attemptersPrior suicide attemptsRegional gray matter volumeFrontolimbic structuresNonattempter groupFrontolimbic systemsHigh riskSignificant negative correlationFunctional MROrbitofrontal cortexSuicidal behavior
2000
Increased anterior cingulate and caudate activity in bipolar mania
Blumberg H, Stern E, Martinez D, Ricketts S, de Asis J, White T, Epstein J, McBride P, Eidelberg D, Kocsis J, Silbersweig D. Increased anterior cingulate and caudate activity in bipolar mania. Biological Psychiatry 2000, 48: 1045-1052. PMID: 11094137, DOI: 10.1016/s0006-3223(00)00962-8.Peer-Reviewed Original ResearchConceptsManic stateAnterior cingulateBipolar disorderHead of caudateFunctional brain abnormalitiesPositron emission tomography techniquesDorsal anterior cingulateEmission tomography techniquesBipolar maniaBrain abnormalitiesSuch dysfunctionCingulateDisordersBrain activityCaudate activityCaudateManiaNeural systemsPrincipal findingsDysfunctionActivityAbnormalitiesEuthymiaExecutive controlFindings