2022
Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
van Velzen LS, Dauvermann MR, Colic L, Villa LM, Savage HS, Toenders YJ, Zhu AH, Bright JK, Campos AI, Salminen LE, Ambrogi S, Ayesa-Arriola R, Banaj N, Başgöze Z, Bauer J, Blair K, Blair RJ, Brosch K, Cheng Y, Colle R, Connolly CG, Corruble E, Couvy-Duchesne B, Crespo-Facorro B, Cullen KR, Dannlowski U, Davey CG, Dohm K, Fullerton JM, Gonul AS, Gotlib IH, Grotegerd D, Hahn T, Harrison BJ, He M, Hickie IB, Ho TC, Iorfino F, Jansen A, Jollant F, Kircher T, Klimes-Dougan B, Klug M, Leehr EJ, Lippard ETC, McLaughlin KA, Meinert S, Miller AB, Mitchell PB, Mwangi B, Nenadić I, Ojha A, Overs BJ, Pfarr JK, Piras F, Ringwald KG, Roberts G, Romer G, Sanches M, Sheridan MA, Soares JC, Spalletta G, Stein F, Teresi GI, Tordesillas-Gutiérrez D, Uyar-Demir A, van der Wee NJA, van der Werff SJ, Vermeiren RRJM, Winter A, Wu MJ, Yang TT, Thompson PM, Rentería ME, Jahanshad N, Blumberg HP, van Harmelen AL, Schmaal L. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium. Molecular Psychiatry 2022, 27: 4550-4560. PMID: 36071108, PMCID: PMC9734039, DOI: 10.1038/s41380-022-01734-0.Peer-Reviewed Original ResearchConceptsMood disordersSuicidal thoughtsSuicide attemptsBrain alterationsMRI metricsSuicidal ideationColumbia-Suicide Severity Rating ScaleStructural brain alterationsLifetime suicide attemptsSeverity Rating ScaleCurrent suicidal ideationActual suicide attemptsHealthy controlsAssessment instrumentsClinical controlEarly interventionMental disordersSignificant associationFrontal poleBrain morphologySuicide riskSuicide attemptersRating ScaleYoung peopleDisorders
2018
Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders
Fan S, Lippard ETC, Sankar A, Wallace A, Johnston JAY, Wang F, Pittman B, Spencer L, Oquendo MA, Blumberg HP. Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders. Journal Of Affective Disorders 2018, 245: 1089-1097. PMID: 30699851, PMCID: PMC6903411, DOI: 10.1016/j.jad.2018.11.095.Peer-Reviewed Original ResearchConceptsMajor depressive disorderYoung adult suicide attemptersNon-suicide attemptersAdult suicide attemptersBipolar disorderSuicide attemptersFractional anisotropyDepressive disorderGM volumePrevention strategiesBrain circuitryYoung adultsBrain circuitry abnormalitiesAdolescents/young adultsWhite matter fractional anisotropyEarly prevention strategiesAdolescence/young adulthoodMagnetic resonance scanningWhite matter alterationsGray matter volumeSuicide prevention strategiesPrior suicide attemptsWM fractional anisotropyWhole-brain analysisWhite matter differences