2022
Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder
Sankar A, Scheinost D, Goldman DA, Drachman R, Colic L, Villa LM, Kim JA, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie CM, Oquendo MA, Constable RT, Blumberg HP. Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder. Translational Psychiatry 2022, 12: 7. PMID: 35013103, PMCID: PMC8748935, DOI: 10.1038/s41398-021-01767-z.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity distributionBipolar disorderSuicide attemptsHealthy volunteersFunctional connectivity disturbancesSuicide behaviorWhole-brain functional connectivityPrior suicide attemptsRight anterior insulaBrain functional connectivitySuicidal ideation severityBilateral ventromedial prefrontal cortexFunctional magnetic resonanceSignificant group differencesTemporopolar cortexConnectivity disturbancesBrain targetsFC differencesHigh riskCerebellar cortexVentromedial prefrontal cortexSuicidal ideationOrbitofrontal cortexFunctional connectivitySuicide riskNeuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review
Rajashekar N, Blumberg HP, Villa LM. Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review. Journal Of Psychiatry And Brain Science 2022, 7: e220006. PMID: 36092855, PMCID: PMC9453888, DOI: 10.20900/jpbs.20220006.Peer-Reviewed Original ResearchBipolar disorderWhite matterBrain regionsBrain differencesDiffusion-weighted magnetic resonance imaging studiesOlder adultsMagnetic resonance imaging studyMood-stabilizing medicationsWhite matter findingsGray matter reductionsLater lifeCommon mood disorderYounger age groupsResonance imaging studyStructural brain differencesSubcortical brain regionsAdverse outcomesCognitive dysfunctionBrain changesClinical dataMood disordersProtective effectElevated riskHigh riskCognitive symptoms
2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder
Johnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderWhite matter integrityFunctional connectivityMatter volumeSuicide attemptsAttempt lethalityPrefrontal connectivitySuicidal ideationYoung adult suicide attemptersAmygdala-prefrontal functional connectivityYoung adultsAmygdala functional connectivitySuicide-related symptomsAdult suicide attemptersPrior suicide attemptsRegional gray matter volumeFrontolimbic structuresNonattempter groupFrontolimbic systemsHigh riskSignificant negative correlationFunctional MROrbitofrontal cortexSuicidal behavior