2022
Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project
Beunders A, Klaus F, Kok A, Schouws S, Kupka R, Blumberg H, Briggs F, Eyler L, Forester B, Forlenza O, Gildengers A, Jimenez E, Mulsant B, Patrick R, Rej S, Sajatovic M, Sarna K, Sutherland A, Yala J, Vieta E, Villa L, Korten N, Dols A. Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project. Bipolar Disorders 2022, 25: 43-55. PMID: 36377516, PMCID: PMC10265276, DOI: 10.1111/bdi.13271.Peer-Reviewed Original ResearchConceptsBD II patientsStudy cohortBD subtypesSomatic burdenMultivariable analysisGeneral functioningBD-IIGlobal AGEingBD-I patientsCross-sectional analysisClinical factorsClinical differencesSevere depressionPsychiatric hospitalizationBipolar ICognitive impairmentLate onsetPatientsOlder ageDiagnostic definitionSubtypesGeneralized linear mixed modelCohortLinear mixed modelsRandom interceptIllness Chronology, Brain Morphology and Mixed Symptom Presentations in Older Age Bipolar Disorder: Emerging Findings from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE –BD) Project
Sajatovic M, Lavin P, Blumberg H, Eyler L. Illness Chronology, Brain Morphology and Mixed Symptom Presentations in Older Age Bipolar Disorder: Emerging Findings from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE –BD) Project. American Journal Of Geriatric Psychiatry 2022, 30: s8-s9. DOI: 10.1016/j.jagp.2022.01.263.Peer-Reviewed Original ResearchOlder age bipolar disorderBipolar disorderAge-related changesSymptom presentationEvolution of BDLate-onset bipolar disorderBrain structuresMajority of patientsOnset of illnessCourse of illnessGlobal AGEingWorse health outcomesGray matter volumeAge of onsetStructural magnetic resonance imaging (MRI) dataMixed featuresClinical factorsEarly mortalityMixed symptomsWhite matter microstructureClinical correlatesCorrelates of ageDepressive episodeFunctional statusRisk factors
2017
Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder
Weathers J, Lippard ETC, Spencer L, Pittman B, Wang F, Blumberg HP. Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 57: 111-117. PMID: 29413143, PMCID: PMC5806147, DOI: 10.1016/j.jaac.2017.11.014.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsDiffusion tensor imaging studyAdolescence/young adulthoodLongitudinal diffusion tensor imaging studyBipolar disorderVentral prefrontal cortexFractional anisotropyYoung adultsHealthy controlsWhite matterImaging studiesUncinate fasciculusYoung adulthoodUF fractional anisotropyWhole-brain analysisClinical factorsTime-related changesSignificant interactionLongitudinal neuroimagingPrefrontal cortexDTI scansNeurodevelopmental pathophysiologyAdultsAgeTrait features